Assessing the quality of reports of randomized trials in pediatric complementary and alternative medicine.
Assessing the quality of reports of randomized trials in pediatric complementary and alternative medicine.
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DOI：
10.1186/1471-2431-2-2
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发表时间：
2002
期刊：
影响因子：
2.4
通讯作者：
Berman B
中科院分区：
文献类型：
--
作者：
Moher D;Sampson M;Campbell K;Beckner W;Lepage L;Gaboury I;Berman B
评价儿科人群补充和替代医学（CAM）随机对照试验（RCT）的报告质量。我们还审查了报告质量是否随时间发生变化。我们使用了251份使用CAM干预的RCT报告的系统样本。使用包含的CONSORT检查表项目数量、不明确分配隐藏的频率和5分质量评估工具来评估每份报告的质量。CONSORT清单中近一半（40%）的项目被列入报告，而且列入的项目数量有所增加。大多数（81.3%）RCT报告分配隐藏不明确，随时间推移无显著变化。报告的质量达到了Jadad量表评估的最高可能总分的约40%，没有随时间变化。不到四分之一的RCT（22%）报告了不良事件信息，仅少数报告（4%）提到了费用信息。随机对照试验是基于证据的医疗保健决策的重要工具。如果这些研究与CAM干预措施的评价相关，则重要的是它们以尽可能高的标准进行和报告。有必要加倍努力，确保儿童及其家庭参与随机对照试验，这些试验的开展和报告应尽量减少偏见。这些研究将增加其对感兴趣的利益攸关方的有用性。
To evaluate the quality of reports of complementary and alternative medicine (CAM) randomized controlled trials (RCTs) in the pediatric population. We also examined whether there was a change in the quality of reporting over time. We used a systematic sample of 251 reports of RCTs that used a CAM intervention. The quality of each report was assessed using the number of CONSORT checklist items included, the frequency of unclear allocation concealment, and a 5-point quality assessment instrument. Nearly half (40%) of the CONSORT checklist items were included in the reports, with an increase in the number of items included. The majority (81.3%) of RCTs reported unclear allocation concealment with no significant change over time. The quality of reports achieved approximately 40% of their maximum possible total score as assessed with the Jadad scale with no change over time. Information regarding adverse events was reported in less than one quarter of the RCTs (22%) and information regarding costs was mentioned in only a minority of reports (4%). RCTs are an important tool for evidence based health care decisions. If these studies are to be relevant in the evaluation of CAM interventions it is important that they are conducted and reported with the highest possible standards. There is a need to redouble efforts to ensure that children and their families are participating in RCTs that are conducted and reported with minimal bias. Such studies will increase their usefulness to a board spectrum of interested stakeholders.