THE CONE ELECTRODE - A LONG-TERM ELECTRODE THAT RECORDS FROM NEURITES GROWN ONTO ITS RECORDING SURFACE
THE CONE ELECTRODE - A LONG-TERM ELECTRODE THAT RECORDS FROM NEURITES GROWN ONTO ITS RECORDING SURFACE
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DOI：
10.1016/0165-0270(89)90142-8
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发表时间：
1989-09-01
影响因子：
3
通讯作者：
KENNEDY, PR
中科院分区：
文献类型：
--
作者：
KENNEDY, PR
一种新型的长期记录电极将神经再生与标准的导线记录技术相结合。电极由固定在中空玻璃锥内的绝缘金线组成。将大鼠坐骨神经置于玻璃锥内，植入大鼠大脑皮质。皮质神经突从周围的神经元生长到锥体中的坐骨神经中，并且它们的电活动通过锥体中的导线（或多根导线）被记录。这种活性在植入后的前几周内幅度增加，并保持稳定，直到数月后实验结束。单个和多个单元的活动都已被记录。锥电极打开独特的机会，在体内的神经突生长的研究，对一组俘虏的神经突的可塑性研究，为研究行为和运动学习的神经相关性，并访问严重麻痹和沟通障碍患者的中枢神经系统。
A novel long-term recording electrode combines neural regeneration with a standard wire recording technique. The electrode consists of an insulated gold wire fixed inside a hollow glass cone. A piece of sciatic nerve is placed in the glass cone before implantation in cortex of rat. Cortical neurites grow into the sciatic nerve in the cone from surrounding neurons and their electrical activity is recorded via the wire (or wires) in the cone. This activity increases in amplitude over the first few weeks after implantation and remains stable until termination of the experiment many months later. Activity of both single and multi units has been recorded. The cone electrode opens unique opportunities for studies of neurite growth in vivo, for plasticity studies on a captive set of neurites, for studying the neural correlates of behavior and motor learning, and for accessing the central nervous systems of patients with severe paralysing and communicative disorders.