Macrophage apoptosis in host immunity to mycobacterial infections
Macrophage apoptosis in host immunity to mycobacterial infections
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DOI：
10.1042/bst0320496
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发表时间：
2004-06-01
影响因子：
3.9
通讯作者：
Fairbairn, IP
中科院分区：
文献类型：
--
作者：
Fairbairn, IP
巨噬细胞凋亡发生在肉芽肿内，这是成功免疫结核病所必需的。体外巨噬细胞凋亡与细胞内结核分枝杆菌的杀伤有关。对这些观察结果的更好理解将导致新的免疫疗法和改进的疫苗设计。本文综述了相关的凋亡刺激物、它们刺激的抗分枝杆菌机制及其生理相关性。
Macrophage apoptosis occurs within the granuloma, which is essential for successful immunity to tuberculosis. In vitro macrophage apoptosis is associated with the killing of intracellular Mycobacterium tuberculosis. A greater understanding of these observations will lead to new immunotherapies and improved vaccine design. The relevant apoptotic stimuli, the anti-mycobacterial mechanisms that they stimulate and their physiological relevance are reviewed in this paper.