Spectroscopy enhances the information content of optical mammography
Spectroscopy enhances the information content of optical mammography
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DOI：
10.1117/1.1427050
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发表时间：
2002-01-01
影响因子：
3.5
通讯作者：
Tromberg, BJ
中科院分区：
文献类型：
--
作者：
Cerussi, AE;Jakubowski, D;Tromberg, BJ
近红外(NIR)漫反射光谱和成像可能会增强现有的乳腺癌筛查、诊断和治疗技术。近红外光谱技术是基于对健康组织和患病组织之间功能对比的定量测量。在这项研究中，我们使用七波长频域光子迁移仪测量了30名健康女性和1名纤维腺瘤患者乳房组织吸收(Mu(A))和散射减少(Mu(S)‘)的光谱依赖性。研究对象包括18岁到之间的绝经前和绝经后女性。使用多光谱测量和四组分拟合来确定乳房中脱氧和氧合血红蛋白、水和脂肪的浓度。并对其散射光谱形状进行了量化。我们的测量表明，测量的近红外分析物浓度与已知的乳房生理很好地相关。虽然在单一波长下的组织散射被发现作为一个功能参数的价值很小，但散射对波长的依赖提供了对乳房成分和生理的关键洞察。随着体重指数的增加，乳房中的脂类和散射光谱分别增加和减少。还提供了简单的计算，以证明忽略水和脂肪在乳房测量中的作用可能会产生不利影响。最后，水是检测纤维腺瘤的一个可能的指标，而血红蛋白饱和度被发现是一个不好的指标。与仅限于一个或两个波长的测量相比，多光谱测量提供了可能对管理乳房疾病有用的额外信息。(C)2002年光学仪器工程师学会。
Near-infrared (NIR) diffuse optical spectroscopy and imaging may enhance existing technologies for breast cancer screening, diagnosis, and treatment. NIR techniques are based on quantitative measurements of functional contrast between healthy and diseased tissue. In this study we measured the spectral dependence of tissue absorption (mu(a)) and reduced scattering (mu(s)') in the breasts of 30 healthy women and one woman with a fibroadenoma using a seven-wavelength frequency-domain photon migration probe. Subjects included pre- and postmenopausal women between the ages of 18 and 64. Multi-spectral measurements were used along with a four-component fit to determine the concentrations of de-oxy and oxyhemoglobin, water and lipids in breast. The scattering spectral shape was also quantified. Our measurements demonstrate that the measured concentrations of NIR analytes correlate well with known breast physiology. Although the tissue scattering at a single wavelength was found to have little value as a functional parameter, the dependence of the scattering on wavelength provided key insights into breast composition and physiology. Lipids and scattering spectra in the breast were found to increase and decrease, respectively, with increasing body mass index. Simple calculations are also provided to demonstrate potential penalties from ignoring the contributions of water and lipids in breast measurements. Finally, water is shown to be a possible indicator for detecting a fibroadenoma, whereas the hemoglobin saturation was found to be a poor indicator. Multi-spectral measurements, compared to measurements restricted to one or two wavelengths, provide additional information that may be useful in managing breast disease. (C) 2002 Society of Photo-Optical Instrumentation Engineers.