Multiple combined therapy for severe Henoch-Schonlein nephritis in children
Multiple combined therapy for severe Henoch-Schonlein nephritis in children
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DOI：
10.1007/s004670050447
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发表时间：
1998-04-01
影响因子：
3
通讯作者：
Yoshikawa, N
中科院分区：
文献类型：
--
作者：
Iijima, K;Ito-Kariya, S;Yoshikawa, N
从1980年至1992年，14例表现为严重肾小球改变（IV级或V级）的Henoch-Schonlein肾炎（HSN）患儿接受了泼尼松龙、环磷酰胺、肝素/华法林和潘生丁的多重联合治疗，并随访7.5 ± 0.9年。从肾炎发作到开始治疗的时间为0.8 ± 0.4年。10例患者在治疗后进行了随访活检。治疗后肾小球新月体/节段性病变的百分比显著降低（70% ± 5% vs. 42% ± 7%，P
From 1980 through 1992, 14 children with Henoch-Schonlein nephritis (HSN) showing severe glomerular changes (grade IV or V) were given a multiple combined therapy with prednisolone, cyclophosphamide, heparin/ warfarin, and dipyridamole, and were followed for 7.5 +/- 0.9 years. The period between the onset of nephritis and the start of therapy was 0.8 +/- 0.4 years. Ten patients underwent follow-up biopsy after therapy. The percentage of glomeruli having crescents/segmental lesions was significantly reduced after therapy (70% +/- 5% vs. 42% +/- 7%, P