GASTROINTESTINAL COLONIZATION WITH YEAST SPECIES AND CANDIDA SEPTICEMIA IN VERY-LOW-BIRTH-WEIGHT INFANTS
GASTROINTESTINAL COLONIZATION WITH YEAST SPECIES AND CANDIDA SEPTICEMIA IN VERY-LOW-BIRTH-WEIGHT INFANTS
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DOI：
10.1111/myc.1990.33.1.20
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发表时间：
1990-01-01
期刊：
影响因子：
4.9
通讯作者：
BANISTER, E
中科院分区：
文献类型：
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作者：
PAPPUKATIKANENI, LD;RAO, KPP;BANISTER, E
酵母菌可能通过插管、静脉导管插入术或直接从肠道吸收等途径进入血液。当肠道中的酵母菌数量超过阈值时，后一种途径变得重要，该阈值可能因动物物种而异。在一项前瞻性研究中，在40名极低出生体重婴儿出生后的前6周内，采用连续的每周两次定量粪便培养，我们发现阈值为8 × 10 - 6。106念珠菌菌落形成单位/克粪便。超过这个阈值，50%的婴儿在大量定植后1至3周内出现胃肠道症状，28.5%的婴儿出现全身性败血症。胃肠道定植率为62.5%（25/40），其中66%的念珠菌菌落形成单位> 8x。106/g粪便。
Yeasts may gain entry into the blood via routes such as intubation, intravenous catheterization or by direct persorption from the gut. The latter route becomes important when the numbers of commensal yeasts in the gut exceeds a threshold which may vary between animal species. In a prospective study utilizing serial, twice weekly quantitative stool cultures during the first 6 weeks of life of 40 very low birth weight infants, we found a threshold of 8 .times. 106 Candida colony-forming units/gram of stool. Beyond this threshold 50% of the infants developed gastrointestinal symptoms and 28.5% developed systemic sepsis within 1 to 3 weeks of heavy colonization. The gastrointestinal colonization rate was 62.5% (25/40) with 66% having Candida colony-forming units > 8 .times. 106/g stool.