HMGA2 overexpression plays a critical role in the progression of esophageal squamous carcinoma.
HMGA2 overexpression plays a critical role in the progression of esophageal squamous carcinoma.
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DOI：
10.18632/oncotarget.8288
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发表时间：
2016-05-03
期刊：
影响因子：
--
通讯作者：
Ribeiro Pinto LF
中科院分区：
文献类型：
--
作者：
Palumbo A Jr;Da Costa NM;Esposito F;De Martino M;D'Angelo D;de Sousa VP;Martins I;Nasciutti LE;Fusco A;Ribeiro Pinto LF
Esophageal Squamous Cell Carcinoma (ESCC) is the most common esophageal tumor worldwide. However, there is still a lack of deeper knowledge about biological alterations involved in ESCC development. High Mobility Group A (HMGA) protein family has been related with poor outcome and malignant cell transformation in several tumor types. In this way, the aim of this study was to analyze the expression of HMGA1 and HMGA2 expression in ESCC and their role in crucial cellular features. We evaluated HMGA1 and HMGA2 mRNA expression in 52 paired ESCC and normal surrounding tissue samples by qRT-PCR. Here, we show that HMGA2, but not HMGA1, is overexpressed in ESCC samples. This result was further confirmed by the immunohistochemical analysis. Indeed, accordingly to mRNA expression data, HMGA2, but not HMGA1, was overexpressed in approximately 90% of ESCC samples, while it was barely expressed in the respective control. Conversely, HMGA1, but not HMGA2, was overexpressed in esophageal adenocarcinoma samples. Interestingly, HMGA2 abrogation attenuated the malignant phenotype of two ESCC cell lines, suggesting that HMGA2 overexpression is involved in ESCC progression.
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影响因子：
--
作者：
Galdiero F;Romano A;Pasquinelli R;Pignata S;Greggi S;Vuttariello E;Bello AM;Calise C;Scaffa C;Pisano C;Losito NS;Fusco A;Califano D;Chiappetta G
通讯作者：
Chiappetta G
影响因子：
2.9
作者：
Soto, AM;Sonnenschein, C
通讯作者：
Sonnenschein, C
影响因子：
5.2
作者：
Lee, Junhyun;Ha, Shinjung;Lee, Han Hong
通讯作者：
Lee, Han Hong
高迁移率A2是头颈鳞状细胞癌中miRNA-98的靶标。
影响因子：
37.3
作者：
Hebert, Carla;Norris, Kathleen;Scheper, Mark A;Nikitakis, Nikolaos;Sauk, John J
通讯作者：
Sauk, John J
影响因子：
5.3
作者：
JOHNSON, KR;LEHN, DA;REEVES, R
通讯作者：
REEVES, R