Age-related changes in Na+ excretion in saline-loaded spontaneously hypertensive rats.
Age-related changes in Na+ excretion in saline-loaded spontaneously hypertensive rats.
复制标题
盐水负荷自发性高血压大鼠钠排泄的年龄相关变化。
DOI：
10.1152/ajplegacy.1976.231.5.1364
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发表时间：
1976
期刊：
影响因子：
--
通讯作者：
R. O. Banks
中科院分区：
文献类型：
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作者：
M. M. Mullins;R. O. Banks
评价了6至7、12至13和16至17周龄自发性高血压大鼠（SHR）排泄急性给药等渗盐水负荷（相当于4.5%体重）的能力。研究了来自两个不同群体的雌性SHR。Wistar（W）和Wistar-Kyoto（WKY）雌性大鼠作为对照。6周龄时，两个SHR群体60 min后排出的Na+负荷分数均显著低于Wistar大鼠，但无显著差异，其中一个群体60 min后排出的Na+显著高于其他大鼠。肾小球滤过率在控制期间与年龄呈正相关，在一个SHR殖民地，没有年龄相关的变化，在其他组的肾小球功能。这些数据1）表明WKY大鼠比Wistar大鼠更适合作为SHR肾功能的对照，2）证明SHR排泄急性给药钠负荷的能力等于或大于血压正常的WKY对照，3）证明就肾功能参数而言，SHR不是同质品系。
The ability of 6- to 7-, 12- to 13-, and 16- to 17-wk-old spontaneously hypertensive rats (SHR) to excrete an acutely administered, isotonic saline load (equivalent to 4.5% body wt) was evaluated. Female SHR from two different colonies were studied. Age-matched female Wistar (W) and Wistar-Kyoto (WKY) rats served as controls. At age 6 wk, the fraction of administered Na+ load excreted by either SHR colony after 60 min was significantly lower than in the Wistar rats but not significank, one colony of SHR excreted significantly more sodium after 60 min than the other rats. Glomerular filtration rate during control periods was positively correlated with age in one SHR colony; no age-related changes were observed in glomerular function in the other groups. These data 1) suggest that WKY rats are more appropriate than the Wistar rats as controls for renal function in the SHR, 2) demonstrate that the ability of the SHR to excrete an acutely administered sodium load is equal to or greater than normotensive WKY controls, and 3) demonstrate that with respect to renal function parameters, the SHR is not a homogenous strain.