Dual effect of nitric oxide donor on adjuvant arthritis
Dual effect of nitric oxide donor on adjuvant arthritis
复制标题
DOI：
10.1016/j.intimp.2009.01.009
复制
发表时间：
2009-04-01
影响因子：
5.6
通讯作者：
Thabit, Romany H.
中科院分区：
文献类型：
--
作者：
Gomaa, Adel A.;Elshenawy, Mohsen M.;Thabit, Romany H.
医学上使用NO供体对关节炎发病机制的影响尚不清楚。我们研究了一氧化氮供体硝普钠（SNP）对大鼠关节炎发病机制的影响。在接种佐剂后的第5天至第14天（作为预防方案）或第16天至第25天（作为治疗方案）腹膜内给予大鼠SNP。无论是预防性还是治疗性，以0.1和1 mg/kg/d的剂量施用SNP显著加重大鼠佐剂性关节炎的发病机制。SNP治疗组大鼠心肌细胞凋亡率明显高于对照组（P
The effect of medical use of NO donors on the pathogenesis of arthritis is still yet unclear. We investigated the effects of the NO donor, sodium nitroprusside (SNP), on the pathogenesis of adjuvant-induced arthritis in rats. Rats were given SNP intraperitoneally either from day 5 to day 14 (as a prophylactic protocol) or from day 16 to day 25 (as a therapeutic protocol) after inoculation of adjuvant. SNP administration, whether prophylactic or therapeutic, in doses of 0.1 and 1 mg/kg/d significantly aggravated pathogenesis of adjuvant arthritis in rats. SNP-treated rats showed significant (P