Deformable registration of the planning image (kVCT) and the daily images (MVCT) for adaptive radiation therapy
Deformable registration of the planning image (kVCT) and the daily images (MVCT) for adaptive radiation therapy
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DOI：
10.1088/0031-9155/51/17/015
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发表时间：
2006-09-07
影响因子：
3.5
通讯作者：
Kupelian, Patrick A.
中科院分区：
文献类型：
--
作者：
Lu, Weiguo;Olivera, Gustavo H.;Kupelian, Patrick A.
将日常图像纳入放射治疗过程导致自适应放射治疗（ART），其中定期评估治疗，并针对剩余的放射治疗过程自适应地修改计划。计划图像和日常图像之间的可变形配准是ART的关键组成部分。在本文中，我们报告了我们的研究计划kVCT和日常MVCT图像集之间的可变形配准。该方法是基于一个快速的基于强度的自由形式的可变形配准技术。考虑到kVCT和MVCT之间的噪声和对比度分辨率差异，在可变形配准过程之前对MVCT图像应用“边缘保持平滑”。我们回顾性研究了来自不同临床中心的商用TomoTherapy机器的每日MVCT图像。数据集包括5个头颈部病例、1个骨盆病例、2个肺部病例和1个前列腺病例。每个病例有1个kVCT图像和20-40个MVCT图像。我们将MVCT图像与其相应的kVCT图像配准。医生对轮廓匹配的相似性测量和目视检查验证了该技术。变形配准在ART中的应用，包括整个放疗过程中的“变形剂量累积”，“自动重新轮廓”和“肿瘤生长/消退评估”也进行了研究。
The incorporation of daily images into the radiotherapy process leads to adaptive radiation therapy ( ART), in which the treatment is evaluated periodically and the plan is adaptively modified for the remaining course of radiotherapy. Deformable registration between the planning image and the daily images is a key component of ART. In this paper, we report our researches on deformable registration between the planning kVCT and the daily MVCT image sets. The method is based on a fast intensity-based free-form deformable registration technique. Considering the noise and contrast resolution differences between the kVCT and the MVCT, an `edge-preserving smoothing' is applied to the MVCT image prior to the deformable registration process. We retrospectively studied daily MVCT images from commercial TomoTherapy machines from different clinical centers. The data set includes five head-neck cases, one pelvis case, two lung cases and one prostate case. Each case has one kVCT image and 20-40 MVCT images. We registered the MVCT images with their corresponding kVCT image. The similarity measures and visual inspections of contour matches by physicians validated this technique. The applications of deformable registration in ART, including `deformable dose accumulation', `automatic re-contouring' and `tumour growth/regression evaluation' throughout the course of radiotherapy are also studied.