Age-related thymic atrophy in the guinea pig
Age-related thymic atrophy in the guinea pig
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DOI：
10.1016/s0145-305x(00)00071-9
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发表时间：
2001-06-01
影响因子：
2.9
通讯作者：
Kraus, VB
中科院分区：
文献类型：
--
作者：
Hale, LP;Clark, AG;Kraus, VB
我们描述了豚鼠年龄相关的胸腺萎缩，包括鉴定抗体，允许免疫组织化学评估胸腺生成。与其他啮齿类动物模型相比，豚鼠年龄相关的胸腺萎缩在组织学上和胸腺重量、细胞结构和功能面积百分比上更接近于人类。因此，豚鼠模型特别适合研究胸腺血管周围空间在年龄相关性胸腺萎缩中的作用。接下来，我们测试了膳食补充维生素C可以预防或延缓与年龄相关的胸腺萎缩的假设。从4个月大开始每天服用3、30或150毫克维生素C的两组在12个月时胸腺组织学、重量、细胞结构和功能面积百分比没有差异。因此，长期补充高达130毫克/公斤/天的维生素C不足以影响豚鼠年龄相关性胸腺萎缩的时间进程和程度，(C) 2001 Elsevier Science Ltd，版权所有。
We have characterized age-related thymic atrophy in the guinea pig, including identification of antibodies that allow immunohistochemical assessment of thymopoiesis. Age-related thymic atrophy in guinea pigs more closely resembles what occurs in humans histologically and in thymus weight, cellularity, and percent functional area than do other rodent models. The guinea pig model is thus particularly well-suited to study the role of the thymic perivascular space in age-related thymic atrophy. We next tested the hypothesis that dietary supplementation with Vitamin C could prevent or delay age-related thymic atrophy. Thymus histology, weight, cellularity, and percent functional area did not differ at 12 months between groups that received 3, 30, or 150 mg Vitamin C daily from 4 months of age. Thus long-term supplementation with up to 130 mg/kg/day Vitamin C is insufficient to influence the time course and extent of age-related thymic atrophy in guinea pigs, (C) 2001 Elsevier Science Ltd, All rights reserved.