Extracellular matrix metalloproteinases in tumor invasion and metastasis.
Extracellular matrix metalloproteinases in tumor invasion and metastasis.
复制标题
细胞外基质金属蛋白酶在肿瘤侵袭和转移中的作用。
DOI：
10.1007/978-1-4615-3940-7_20
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发表时间：
1991
影响因子：
--
通讯作者：
Eisen,AZ
中科院分区：
文献类型：
--
作者：
Goldberg,GI;Eisen,AZ
近年来，在了解参与哺乳动物细胞外基质（ECM）降解的分泌型金属蛋白酶的结构、功能和基因表达调控方面取得了重大进展。与此同时，一些研究已经产生了间接证据，表明这些蛋白酶与肿瘤的生长、侵袭和转移有关。更详细的讨论这些蛋白酶的性质是本审查的范围之外，但我们在这里总结了现有的数据有关的可能作用，这些酶和纤溶酶原激活剂在肿瘤的发展和转移。
In recent years, significant progress has been made in understanding the structure, function, and regulation of gene expression of secreted metalloproteinases that participate in the degradation of the mammalian extracellular matrix (ECM). At the same time, several lines of investigation have produced circumstantial evidence implicating these proteases in tumor growth, invasion, and metastasis. A more detailed discussion of the properties of these proteases is outside the scope of this review, but we summarize here the available data concerning the possible role of these enzymes and plasminogen activators in tumor development and metastasis.