Reduced frequency of FOXP3+ CD4+CD25+ regulatory T cells in patients with chronic graft-versus-host disease
Reduced frequency of FOXP3+ CD4+CD25+ regulatory T cells in patients with chronic graft-versus-host disease
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DOI：
10.1182/blood-2005-03-1257
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发表时间：
2005-10-15
期刊：
影响因子：
20.3
通讯作者：
Ritz, J
中科院分区：
文献类型：
--
作者：
Zorn, E;Kim, HT;Ritz, J
慢性移植物抗宿主病(CGVHD)是异基因造血干细胞移植的主要并发症，但导致cGVHD临床表现多样化的免疫机制尚不清楚。在这项研究中，我们检测了57名移植受者(30名cGVHD患者和27名非活动性cGVHD患者)和26名健康供者的调节性T细胞(Tregs)。表型研究显示cGVHD患者的CD4(+)CD25(+)T细胞频率低于非cGVHD患者(P
Chronic graft-versus-host disease (cGVHD) is a major complication of allogeneic hematopoietic stem cell transplantation but the immune mechanisms leading to the diverse clinical manifestations of cGVHD remain unknown. In this study, we examined regulatory T cells (Tregs) in 57 transplant recipients (30 with cGVHD and 27 without active cGVHD) and 26 healthy donors. Phenotypic studies demonstrated decreased frequency of CD4(+)CD25(+) T cells in patients with cGVHD compared with patients without cGVHD (P