Conservation of pro-longevity genes among mammals.
Conservation of pro-longevity genes among mammals.
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DOI：
10.1016/j.mad.2015.03.004
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发表时间：
2015-03
影响因子：
5.3
通讯作者：
Pignolo, Robert. J.
中科院分区：
文献类型：
--
作者：
Lindborg, Carter M.;Propert, Kathleen J.;Pignolo, Robert. J.
赋予相对长寿优势的基因可能在转录或翻译水平上受到调控。或者，促长寿基因可能在蛋白质结构-功能关系的水平上介导它们的作用，这种关系在长寿物种中是有益的优化。长寿相关基因（LAGs）可以被操作性地定义为赋予有益效应并且在长寿物种中相对更保守的基因。检查了至少30种哺乳动物物种中超过10，000个基因的全局和局部蛋白质序列比对，以鉴定LAG。通过我们的分析，已知的LAG，包括生长激素受体（GHR）和乳腺癌1，早发性（BRCA 1），与最长寿命有很强的相关性。在所有回归模型确定的与MLS具有最强关联的基因中观察到几种常见的蛋白质功能类别。这些基因包括那些在免疫系统，细胞周期调节和DNA损伤反应中起作用的基因。我们提供了一个排名的基因与物种最大寿命（MLS）的几个系统发育广义最小二乘回归模型，包括调整混杂变量，如体重和妊娠期长度的最强关联。
Genes which confer a relative longevity advantage may be regulated at the level of transcription or translation. Alternatively, pro-longevity genes may mediate their effects at the level of protein structure-functional relationships that are beneficially optimized in long-lived species. Longevity associated genes (LAGs) may be operationally defined as genes that confer beneficial effects and are relatively more conserved among long-lived species. Global and local protein sequence alignments of over 10,000 genes across at least 30 mammalian species were examined to identify LAGs. Known LAGs, including growth hormone receptor (GHR), and breast cancer 1, early onset (BRCA1), have strong associations with maximum lifespan by our analysis. Several common categories of protein function were observed among genes ranked with the strongest associations with MLS identified by all regression models. These genes included those that function in the immune system, cell cycle regulation, and DNA damage response. We provide a ranking of genes with the strongest associations with species maximum lifespan (MLS) by several phylogenetic generalized least squares regression models, including adjustment for confounding variables such as body weight and gestation length.
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影响因子：
3.7
作者：
Semeiks J;Grishin NV
通讯作者：
Grishin NV
DOI：
10.1083/jcb.201009094
发表时间：
2011-02-21
期刊：
The Journal of cell biology
影响因子：
--
作者：
Rodier F;Campisi J
通讯作者：
Campisi J
影响因子：
--
作者：
Arranz, Lorena;Lord, Janet M.;De la Fuente, Monica
通讯作者：
De la Fuente, Monica
影响因子：
30.8
作者：
Puel, A;Ziegler, SF;Leonard, WJ
通讯作者：
Leonard, WJ
影响因子：
4.8
作者：
Yamazaki, T;Hamano, Y;Saito, T
通讯作者：
Saito, T