Iridium-Catalyzed Enantioselective Allyl-Allyl Cross-Coupling of Racemic Allylic Alcohols with Allylboronates
Iridium-Catalyzed Enantioselective Allyl-Allyl Cross-Coupling of Racemic Allylic Alcohols with Allylboronates
复制标题
铱催化外消旋烯丙醇与烯丙基硼酸酯的对映选择性烯丙基-烯丙基交叉偶联
DOI：
10.1021/acs.orglett.8b03627
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发表时间：
2018
期刊：
影响因子：
5.2
通讯作者：
Yang Yu-Rong
中科院分区：
文献类型：
--
作者：
Zheng Yu;Yue Bei-Bei;Wei Kun;Yang Yu-Rong
报道了Carreira的基于铱-（β-烯烃）亚磷酰胺的催化体系，其允许具有高对映选择性的不对称烯丙基-烯丙基硼酸酯交叉偶联。这种转化耐受多种外消旋支链烯丙醇和烯丙基硼酸酯底物。偶联的效用在（-）-preclamol的简洁催化不对称合成中得到证明。
Carreira’s iridium-(P, olefin) phosphoramidite-based catalytic system that allows asymmetric allyl–allylboronate cross-coupling with high enantioselectivity is reported. This transformation tolerates a large variety of racemic branched allylic alcohols and allylboronate substrates. The utility of the coupling is demonstrated in a concise catalytic asymmetric synthesis of (−)-preclamol.