Essential function for SAP family adaptors in the surveillance of hematopoietic cells by natural killer cells
Essential function for SAP family adaptors in the surveillance of hematopoietic cells by natural killer cells
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DOI：
10.1038/ni.1763
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发表时间：
2009-09-01
影响因子：
30.5
通讯作者：
Veillette, Andre
中科院分区：
文献类型：
--
作者：
Dong, Zhongjun;Cruz-Munoz, Mario-Ernesto;Veillette, Andre
衔接子SAP、EAT-2和ERT对免疫系统的细胞具有特异性，并且属于SAP家族。所有这三种都在自然杀伤（NK）细胞中表达。在这里，我们使用缺乏SAP、EAT-2和ERT的小鼠检查了SAP家族的整体功能。这些衔接子在一种机制中共同发挥作用，这种机制对于NK细胞消除造血细胞而不是非造血细胞至关重要。这种功能由NK细胞上的SLAM家族的许多受体介导，这些受体由仅在造血细胞上发现的配体参与。在缺乏SAP相关衔接子的情况下，SLAM受体失去了其激活功能，并成为抑制其他激活受体（如NKG 2D）的抑制性受体。因此，SAP家族对于通过NK细胞消除不需要的造血细胞是必不可少的。
The adaptors SAP, EAT-2 and ERT are specific to cells of the immune system and belong to the SAP family. All three are expressed in natural killer (NK) cells. Here we examined the global function of the SAP family using mice lacking SAP, EAT-2 and ERT. These adaptors acted together in a mechanism that was essential for the elimination of hematopoietic but not nonhematopoietic cells by NK cells. This function was mediated by many receptors of the SLAM family on NK cells that were engaged by ligands found solely on hematopoietic cells. In the absence of SAP-related adaptors, SLAM receptors lost their activating function and became inhibitory receptors that repressed other activating receptors, such as NKG2D. Hence, the SAP family is essential for the elimination of unwanted hematopoietic cells by NK cells.