Sulfonation, an underexploited area: from skeletal development to infectious diseases and cancer.
Sulfonation, an underexploited area: from skeletal development to infectious diseases and cancer.
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DOI：
10.18632/oncotarget.10046
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发表时间：
2016-08-23
期刊：
影响因子：
--
通讯作者：
Bally MB
中科院分区：
文献类型：
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作者：
Leung AW;Backstrom I;Bally MB
磺化是最丰富的细胞反应之一，可修饰多种外源性物质和内源性分子，调节重要的生物过程，包括凝血、结缔组织的形成以及分泌蛋白、激素和信号分子的功能。磺化作用在所有组织中普遍存在，并且在自然界（植物、动物和微生物）中广泛存在。尽管磺基结合物在一个多世纪前就被发现了，当时鲍曼于 1875 年在一位服用苯酚作为防腐剂的患者的尿液中分离出了苯硫酸盐，但磺化的重要性及其在人类疾病中的作用直到最近几年才得到充分认识。在这里，我们概述了磺化反应在各种生物功能和医疗条件（重点是癌症）中的重要性。如果我们要充分了解磺化缺陷如何影响人类健康，我们还讨论了值得进一步关注的研究领域，这反过来又有助于确定改善健康的治疗方法。
Sulfonation is one of the most abundant cellular reactions modifying a wide range of xenobiotics as well as endogenous molecules which regulate important biological processes including blood clotting, formation of connective tissues, and functionality of secreted proteins, hormones, and signaling molecules. Sulfonation is ubiquitous in all tissues and widespread in nature (plants, animals, and microorganisms). Although sulfoconjugates were discovered over a century ago when, in 1875, Baumann isolated phenyl sulfate in the urine of a patient given phenol as an antiseptic, the significance of sulfonation and its roles in human diseases have been underappreciated until recent years. Here, we provide a current overview of the significance of sulfonation reactions in a variety of biological functions and medical conditions (with emphasis on cancer). We also discuss research areas that warrant further attention if we are to fully understand how deficiencies in sulfonation could impact human health which, in turn, could help define treatments to effect improvements in health.