Salivary gonadal and adrenal hormone differences in boys and girls with and without disruptive behavior disorders: Contextual variants
Salivary gonadal and adrenal hormone differences in boys and girls with and without disruptive behavior disorders: Contextual variants
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DOI：
10.1016/j.biopsycho.2009.01.004
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发表时间：
2009-04-01
影响因子：
2.6
通讯作者：
Bukstein, Oscar G.
中科院分区：
文献类型：
--
作者：
Dorn, Lorah D.;Kolko, David J.;Bukstein, Oscar G.
精神病理组和性别的激素差异可能会对理解破坏性行为障碍(DBD)和治疗结果的复杂性产生影响。目前的理论模型强调背景差异是荷尔蒙-行为关系的调节因素。这份基线报告调查了：(A)患有和不患有DBD的年轻人的荷尔蒙差异，以及(B)作为行为问题和荷尔蒙调节因素的背景因素。180名儿童和青少年入选(141名男孩，平均9.0+/-1.7岁)。DBD参与者符合品行障碍(CD)和/或对立违抗障碍(ODD)的标准(n=111)；共招募了69人。作为健康的比较(HC)。收集唾液中的睾酮和皮质醇。脱氢表雄酮和雄烯二酮。DBD青年组的雄烯二酮显著高于HC组。基础皮质醇平均值存在性别交互作用，DBD男孩和HC女孩皮质醇水平较低。在皮质醇和肾上腺雄激素方面，注意到了环境变量(例如，家庭功能、犯罪同伴)的缓和作用。研究结果表明，除了简单的直接一对一联系外，荷尔蒙对糖尿病的影响也是有道理的。(C)2009爱思唯尔B.V.保留所有权利。
Hormone differences by psychopathology group and gender may have implications for understanding disruptive behavior disorders (DBDs) and complexities of treatment outcomes. Current theoretical models emphasize contextual differences as moderators of hormone-behavior relations. This baseline report examined: (a) hormone differences in youth with and without DBD, and (b) contextual factors as moderators of behavior problems and hormones. 180 children and adolescents were enrolled (141 boys, mean 9.0 +/- 1.7 years). DBD participants met criteria for conduct disorder (CD) and/or oppositional defiant disorder (ODD) (n = 111); 69 were recruited. as healthy comparisons (HC). Saliva was collected for testosterone, cortisol. dehydroepiandrosterone and androstenedione. DBD youth had significantly higher androstenedione than the HC group. There was a group by gender interaction for basal cortisol mean with DBD boys and HC girls having lower cortisol. Moderating effects of contextual variables (e.g., family functioning, delinquent peers) were noted for cortisol and adrenal androgens. Findings argue for considering hormones as an influence on DBD beyond simple direct one-to-one associations. (C) 2009 Elsevier B.V. All rights reserved.