Serum cytokine levels related to multiple dimensions of fatigue in patients with primary Sjogren's syndrome
Serum cytokine levels related to multiple dimensions of fatigue in patients with primary Sjogren's syndrome
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DOI：
10.1136/ard.2003.011825
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发表时间：
2004-10-01
影响因子：
27.4
通讯作者：
Derksen, RHWM
中科院分区：
文献类型：
--
作者：
Hartkamp, A;Geenen, R;Derksen, RHWM
目的：为探讨原发性干燥综合征（primarySjogren 'ssyndrome，pSS）患者血清中细胞因子水平与疲劳的相关性，采用问卷调查的方法，对60例女性pSS患者进行多维度疲劳评估。将评分与基于人群的对照组（n = 139）中的值进行比较。血清中白细胞介素（IL）1 β、IL 2、IL 6、IL 10和肿瘤坏死因子α的水平用商业夹心ELISA法测定。自我报告的疲劳和这些血清细胞因子水平之间的关系determined.Results：pSS患者在疲劳的所有方面都有很高的分数（p< 0.001）：一般疲劳，身体疲劳，活动减少，动机减少，精神疲劳。疲劳程度与血清细胞因子水平无关。偶然发现，减少的动机是较高的患者血清水平的IL 10（p = 0.04）校正后消失的多重testing.Conclusion：疲劳是突出的pSS患者，并涉及所有方面的疲劳。这些发现并不表明循环细胞因子对疲劳的多个方面有广泛的影响。
Objective: To test whether serum levels of selected cytokines relate to different dimensions of fatigue in patients with primary Sjogren's syndrome (pSS).Methods: Sixty female patients with pSS filled out a questionnaire to assess multiple dimensions of fatigue. Scores were compared with values in a population based control group (n = 139). Levels of interleukin (IL) 1beta, IL2, IL6, IL10, and tumour necrosis factor alpha were measured in serum with commercial sandwich ELISAs. The relationship between self reported dimensions of fatigue and these serum cytokine levels was determined.Results: Patients with pSS had high scores at all dimensions of fatigue ( p< 0.001): general fatigue, physical fatigue, reduced activity, reduced motivation, and mental fatigue. Fatigue levels were not related to serum cytokine levels. The incidental finding that reduced motivation was higher in patients with detectable serum levels of IL10 ( p = 0.04) disappeared after correction for multiple testing.Conclusion: Fatigue is prominent in patients with pSS and involves all dimensions of fatigue. The findings do not suggest a widespread effect of circulating cytokines on multiple aspects of fatigue.