Specific and evolving resting-state network alterations in post-concussion syndrome following mild traumatic brain injury.
Specific and evolving resting-state network alterations in post-concussion syndrome following mild traumatic brain injury.
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DOI：
10.1371/journal.pone.0065470
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Lehéricy S
中科院分区：
文献类型：
--
作者：
Messé A;Caplain S;Pélégrini-Issac M;Blancho S;Lévy R;Aghakhani N;Montreuil M;Benali H;Lehéricy S
脑震荡后综合征与轻度创伤性脑损伤患者的轴突损伤有关，但对脑网络损伤的后果知之甚少。在本研究中，我们的目的是描述脑震荡后综合征患者轻度创伤性脑损伤后功能性脑网络的变化，使用静息态功能磁共振成像数据。我们调查了17名受伤的患者在受伤后6个月出现持续性脑震荡后综合征（根据DSM-IV标准），并与38名没有脑震荡后综合征的轻度创伤性脑损伤患者和34名健康对照组进行了比较。所有患者均在伤后亚急性期（1-3周）和晚期（6个月）进行磁共振成像检查。功能性大脑网络的组间差异使用图论方法进行分析。所有轻度创伤性脑损伤患者均存在长程功能网络改变。轻度脑外伤合并脑震荡后综合征的患者比无脑震荡后综合征的患者有更大的改变。在脑震荡后综合征患者中，变化特别影响颞叶和丘脑区域，主要是在亚急性期和额叶区域在晚期。我们的研究结果表明，脑震荡后综合征与功能性脑网络的特定异常有关，这可能有助于解释PCS患者中通常观察到的缺陷。
Post-concussion syndrome has been related to axonal damage in patients with mild traumatic brain injury, but little is known about the consequences of injury on brain networks. In the present study, our aim was to characterize changes in functional brain networks following mild traumatic brain injury in patients with post-concussion syndrome using resting-state functional magnetic resonance imaging data. We investigated 17 injured patients with persistent post-concussion syndrome (under the DSM-IV criteria) at 6 months post-injury compared with 38 mild traumatic brain injury patients with no post-concussion syndrome and 34 healthy controls. All patients underwent magnetic resonance imaging examinations at the subacute (1–3 weeks) and late (6 months) phases after injury. Group-wise differences in functional brain networks were analyzed using graph theory measures. Patterns of long-range functional networks alterations were found in all mild traumatic brain injury patients. Mild traumatic brain injury patients with post-concussion syndrome had greater alterations than patients without post-concussion syndrome. In patients with post-concussion syndrome, changes specifically affected temporal and thalamic regions predominantly at the subacute stage and frontal regions at the late phase. Our results suggest that the post-concussion syndrome is associated with specific abnormalities in functional brain network that may contribute to explain deficits typically observed in PCS patients.
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影响因子：
5.7
作者：
Irimia, Andrei;Chambers, Micah C.;Torgerson, Carinna M.;Van Horn, John D.
通讯作者：
Van Horn, John D.
影响因子：
5.3
作者：
Achard, S;Salvador, R;Bullmore, ET
通讯作者：
Bullmore, ET
影响因子：
3.7
作者：
Humphries MD;Gurney K
通讯作者：
Gurney K
影响因子：
5.7
作者：
Bassett, Danielle S.;Nelson, Brent G.;Mueller, Bryon A.;Camchong, Jazmin;Lim, Kelvin O.
通讯作者：
Lim, Kelvin O.
DOI：
10.1176/appi.neuropsych.17.3.350
发表时间：
2005-06-01
影响因子：
2.9
作者：
Boake, C;McCauley, SR;Diaz-Marchan, PJ
通讯作者：
Diaz-Marchan, PJ