T Helper 2-Associated Immunity in the Pathogenesis of Systemic Lupus Erythematosus.
T Helper 2-Associated Immunity in the Pathogenesis of Systemic Lupus Erythematosus.
复制标题
DOI：
10.3389/fimmu.2022.866549
复制
发表时间：
2022
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
--
作者：
系统性红斑狼疮（SLE）是一种慢性自身免疫性疾病，主要影响育龄妇女。环境和遗传因素的复杂相互作用导致对自身免疫耐受的破坏，导致明显的免疫激活和攻击多个器官的自身抗体的产生。肾损害，称为狼疮性肾炎，是SLE相关发病率和死亡率的主要原因。自身抗体是通过形成免疫复合物和触发补体来传播狼疮肾炎的核心。免疫球蛋白G（IgG）有效激活补体;因此，自身抗体主要被认为是IgG同种型。然而，研究表明，超过50%的患者产生IgE同种型的自身抗体。IgE自身抗体积极参与疾病发病机制，因为奥马珠单抗治疗（一种人源化抗IgE单克隆抗体）在SLE临床试验中改善了疾病严重程度。IgE是辅助性T细胞2相关免疫的标志。因此，辅助性T细胞2相关免疫似乎在SLE患者的一个子集中发挥致病作用。本文综述了人类和动物的研究，说明2型免疫反应参与SLE的病理过程中。
Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease that mainly affects women in their reproductive years. A complex interaction of environmental and genetic factors leads to the disruption of immune tolerance towards self, causing overt immune activation and production of autoantibodies that attack multiple organs. Kidney damage, termed lupus nephritis, is the leading cause of SLE-related morbidity and mortality. Autoantibodies are central to propagating lupus nephritis through forming immune complexes and triggering complements. Immunoglobulin G (IgG) potently activates complement; therefore, autoantibodies were mainly considered to be of the IgG isotype. However, studies revealed that over 50% of patients produce autoantibodies of the IgE isotype. IgE autoantibodies actively participate in disease pathogenesis as omalizumab treatment, a humanized anti-IgE monoclonal antibody, improved disease severity in an SLE clinical trial. IgE is a hallmark of T helper 2-associated immunity. Thus, T helper 2-associated immunity seems to play a pathogenic role in a subset of SLE patients. This review summarizes human and animal studies that illustrate type 2 immune responses involved during the pathology of SLE.