LGR5 is a promising biornarker for patients with stage I and II gastric cancer
LGR5 is a promising biornarker for patients with stage I and II gastric cancer
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DOI：
10.3978/j.issn.1000-9604.2013.01.07
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发表时间：
2013-02-01
影响因子：
5.1
通讯作者：
Ji, Jiafu
中科院分区：
文献类型：
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作者：
Bu, Zhaode;Zheng, Zhixue;Ji, Jiafu
目的：探讨富亮氨酸重复-含G蛋白偶联受体5 （LGR5）在胃癌中的表达及其临床意义。方法：应用免疫组化方法检测257例胃癌术后患者LGR5的表达。统计学分析LGR5表达与临床病理特征及患者预后的关系。结果：作为肿瘤干细胞标志物的LGR5在胃癌中的表达明显高于癌旁正常组织(P
Objective: To investigate Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) expressions in gastric cancer and to evaluate its clinical significance.Methods: LGR5 expression was assessed by immunohistochemistry in 257 gastric cancer patients after surgery. The relationships between LGR5 expression and clinicopathological features and patients prognosis were statistically analyzed.Results: The expression of LGR5 was significantly higher in gastric cancers as a cancer stem cell marker than in adjacent normal tissues (P