Changes in depressive symptoms and glycemic control in diabetes mellitus
Changes in depressive symptoms and glycemic control in diabetes mellitus
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DOI：
10.1097/psy.0b013e318042588d
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发表时间：
2007-04-01
影响因子：
3.3
通讯作者：
Surwit, Richard S.
中科院分区：
文献类型：
--
作者：
Georgiades, Anastasia;Zucker, Nancy;Surwit, Richard S.
研究1型和2型糖尿病患者12个月期间抑郁症状的变化是否与血糖控制的变化相关。研究方法：将90名贝克抑郁量表（BDI）水平> 10的患者（1型糖尿病，n = 28; 2型糖尿病，n = 62）纳入研究。在这90名患者中，65名患者完成了为期12周的认知行为治疗干预。在基线时评估BDI，此后在12个月内每两周评估一次。血红蛋白（HbA 1c）和空腹血糖水平在基线和四个季度的住院随访时进行了评估。应用线性混合模型分析来确定时间和糖尿病类型对抑郁症状、HbA 1c水平和空腹血糖水平的影响。结果如下：基线BDI和HbA 1c水平的平均值和标准差分别为17.9 ± 5.8和7.6 ± 1.6，I型和2型糖尿病患者之间无显著差异。混合模型回归分析发现，在研究期间，I型和2型糖尿病组之间BDI评分对HbA 1c或空腹血糖水平的受试者内影响无差异。抑郁症状显著降低（p = 0.0001），在12个月的时间内，I型和2型糖尿病患者的抑郁症状相似，而HbA 1c和空腹血糖水平在两组中均未随时间发生显著变化。结论：在1型或2型糖尿病患者中，抑郁症状的变化与1年内HbA 1c或空腹血糖水平的变化无关。
To investigate if changes in depressive symptoms would be associated with changes in glycemic control over a 12-month period in patients with Type 1 and Type 2 diabetes. Methods: Ninety (Type 1 diabetes, n = 28; Type 2 diabetes, n = 62) patients having Beck Depression Inventory (BDI) levels of > 10 were enrolled in the study. Of those 90 patients, 65 patients completed a 12-week cognitive behavioral therapy intervention. BDI was assessed at baseline and thereafter biweekly during 12 months. Hemoglobin (HbA1c) and fasting blood glucose levels were assessed at baseline and at four quarterly in-hospital follow-up visits. Linear mixed-model analysis was applied to determine the effects of time and diabetes type on depressive symptoms, HbA1c levels, and fasting glucose levels. Results: Mean and standard deviation baseline BDI and HbA1c levels were 17.9 +/- 5.8 and 7.6 +/- 1.6, respectively, with no significant difference between patients with Type I and Type 2 diabetes. Mixed-model regression analysis found no difference between the groups with Type I and Type 2 diabetes in the within-subject effect of BDI score on HbA1c or fasting glucose levels during the study. Depressive symptoms decreased significantly (p = .0001) and similarly over a 12-month period in both patients with Type I and Type 2 diabetes, whereas HbA1c and fasting glucose levels did not change significantly over time in either group. Conclusion: Changes in depressive symptoms were not associated with changes in HbA1c or fasting glucose levels over a 1-year period in either patients with Type 1 or Type 2 diabetes.