High-level acetaldehyde production in Lactococcus lactic by metabolic engineering
High-level acetaldehyde production in Lactococcus lactic by metabolic engineering
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DOI：
10.1128/aem.71.2.1109-1113.2005
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发表时间：
2005-02-01
影响因子：
4.4
通讯作者：
Kleerebezem, M
中科院分区：
文献类型：
--
作者：
Bongers, RS;Hoefnagel, MHN;Kleerebezem, M
乳酸链球菌素控制的运动发酵单胞菌丙酮酸脱羧酶（pdc）和乳酸乳球菌NADH氧化酶（nox）在乳酸乳球菌中的过表达可有效地将葡萄糖转化为乙醛。乳酸菌。在静止细胞中，几乎50%的消耗的葡萄糖可以在厌氧条件下通过pdc和nox的联合过表达而被重定向为乙醛。
Efficient conversion of glucose to acetaldehyde is achieved by nisin-controlled overexpression of Zymomonas mobilis pyruvate decarboxylase (pdc) and Lactococcus lactis NADH oxidase (nox) in L. lactis. In resting cells, almost 50% of the glucose consumed could be redirected towards acetaldehyde by combined overexpression of pdc and nox under anaerobic conditions.