Aortic Root Dilatation Is Associated With Incident Cardiovascular Events in a Population of Treated Hypertensive Patients: The Campania Salute Network
Aortic Root Dilatation Is Associated With Incident Cardiovascular Events in a Population of Treated Hypertensive Patients: The Campania Salute Network
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DOI：
10.1093/ajh/hpy113
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发表时间：
2018-12-01
影响因子：
3.2
通讯作者：
De Luca, Nicola
中科院分区：
文献类型：
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作者：
Canciello, Grazia;Mancusi, Costantino;De Luca, Nicola
背景在基于人群的研究中，瓦尔萨尔瓦窦的主动脉根部 (AR) 尺寸 (ARD) 与心血管 (CV) 事件相关，但这种影响可能是由于与左心室 (LV) 质量增加有关。如何定义明确的 AR 扩张也存在不确定性。因此，我们分析了坎帕尼亚致敬网络 (CSN) 登记，以 (i) 建立 ARD 评估标准，(ii) 提出 AR 扩张的切点，以及 (iii) 确定 AR 扩张是否具有独立于左室肥厚 (LVH) 的预后价值。 方法我们分析了可进行随访、窦性心律且无流行的瓣膜和心血管疾病的高血压患者 (n = 8,573)。通过与年龄、性别和身高预测值（即 Ao-Z > 0.80）进行比较而获得的 AR 超过 ARz 评分 (Ao-Z) 的第 75 个百分位数，则被认为是扩张。 结果 基线 Ao-Z 扩张的 ARD 患者更有可能更年轻、男性和肥胖，并且基线血压更高（BP；所有
BACKGROUNDAortic root (AR) dimension (ARD) at the Valsalva sinuses has been associated with incident cardiovascular (CV) events in population-based studies, but this effect could be due to the association with increased left ventricular (LV) mass. There is also uncertainty on how to define clear-cut AR dilatation. Thus, we analyzed the Campania Salute Network (CSN) registry to (i) establish criteria for evaluation of ARD, (ii) propose cut-points for AR dilatation, and (iii) determine whether AR dilatation has prognostic value independent of LV hypertrophy (LVH).METHODSWe analyzed hypertensive patients with available follow-up, in sinus rhythm and free of prevalent valvular and CV disease (n = 8,573). AR exceeding the 75th percentile of the ARz-score (Ao-Z) obtained by comparison with the value predicted by age, sex, and height (i.e., Ao-Z > 0.80) was considered dilated.RESULTSPatients with baseline-dilated ARD by Ao-Z were more likely to be younger, men, and obese and had higher baseline blood pressure (BP; all