INTERLEUKIN-6-PRODUCING PHEOCHROMOCYTOMA AS A NEW REASON FOR FEVER OF UNKNOWN ORIGIN: A RETROSPECTIVE STUDY
INTERLEUKIN-6-PRODUCING PHEOCHROMOCYTOMA AS A NEW REASON FOR FEVER OF UNKNOWN ORIGIN: A RETROSPECTIVE STUDY
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DOI：
10.4158/ep-2018-0048
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发表时间：
2018-06-01
影响因子：
4.2
通讯作者：
Ji, Zhigang
中科院分区：
文献类型：
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作者：
Cheng, Xiangming;Zhang, Mingxin;Ji, Zhigang
目的：目的：探讨嗜铬细胞瘤患者不明原因发热（FUO）的发生情况。方法：收集2014年6月至2017年4月间收治的嗜铬细胞瘤患者。记录患者的性别、年龄、24 h尿儿茶酚胺（去甲肾上腺素、肾上腺素、多巴胺）、肿瘤大小、腋温（AT）、白色血细胞（WBC）、血清IL-6和高敏C反应蛋白（hsCRP）水平。结果：29例嗜铬细胞瘤（7例AT增高，22例AT正常）中，21例AT正常，22例AT阴性。与正常AT组相比，高AT组的血清IL-6和hsCRP水平升高（均P = 0.001）。嗜铬细胞瘤切除术后AT、IL-6和hsCRP水平明显下降（P
Objective: To explore the fever of unknown origin (FUO) in patients with interleukin-6 (IL-6)-producing pheochromocytoma.Methods: Patients with pheochromocytoma were enrolled from June 2014 to April 2017. Clinical characteristics were recorded including sex, age, 24-h urinary catecholamines (norepinephrine, epinephrine, dopamine), tumor size, axillary temperature (AT), white blood cells (WBC), and serum IL-6 and high-sensitivity C-reactive protein (hsCRP) levels. IL-6 secretion by pheochromocytoma was analyzed by immunohistochemistry (IHC).Results: We identified 29 cases of pheochromocytoma (7 with high AT and 22 with normal AT). Serum IL-6 and hsCRP levels were increased in the high AT group compared with the normal AT group (both P = .001). After pheochromocytoma resection, AT and IL-6 and hsCRP levels decreased significantly (P