Volume Quantification of Endo lymph after Intravenous Administration of a Single Dose of Gadolinium Contrast Agent: Comparison of 18-versus 8-minute Imaging Protocols
Volume Quantification of Endo lymph after Intravenous Administration of a Single Dose of Gadolinium Contrast Agent: Comparison of 18-versus 8-minute Imaging Protocols
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DOI：
10.2463/mrms.2014-0118
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发表时间：
2015-01-01
影响因子：
3
通讯作者：
Ikeda, Mitsuru
中科院分区：
文献类型：
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作者：
Naganawa, Shinji;Ohashi, Toshio;Ikeda, Mitsuru
目的：我们通过扩展先前提出的不太依赖观察者的面积量化方法来测量内淋巴空间的体积，并比较使用长扫描时间（18 分钟，图像 A）和短扫描时间（8 mm，图像 B）获得的体积测量结果。方法：我们在静脉注射单剂量钆基对比材料 (IV-SD-GBCM) 4 小时后，对 20 名临床怀疑内淋巴积水的患者的 40 只耳朵进行了 MR 成像。两名观察者通过扩展先前报道的面积比测量方法，分别测量了耳蜗和前庭内淋巴体积与总淋巴体积的比率（图A和B）。计算图像 A 和 B 的值之间的相关性。结果：我们观察到耳蜗图像中图像 A 和 B 之间存在很强的线性相关性；观察者 A 的皮尔逊相关系数 (r) 为 0.928，观察者 B 的皮尔逊相关系数 (r) 为 0.926（所有 P < 0.001）。在前庭图像中也观察到很强的线性相关性；观察者 A 的皮尔逊相关系数 (r) 为 0.962，观察者 B 为 0.968（P < 0.001）。 结论：使用 MR 成像方案测量 IV-SD-GBCM 后的内淋巴体积可能是可行的，扫描时间缩短为 8 分钟。该方法可能有助于在临床应用中更多地使用内淋巴积液成像。
Purpose: We measured the volume of the endolymphatic space by extending a previously proposed less observer-dependent method of area quantification and compared volume measurements obtained using long (18 min, Image A) and short (8 mm, Image B) scan times.Methods: We performed MR imaging of 40 ears in 20 patients with clinically suspected endolymphatic hydrops 4 hours after intravenous administration of single-dose gadolinium-based contrast material (IV-SD-GBCM). Two observers separately measured the ratio of the volume of the endolymph to that of total lymph in the cochlea and vestibule by extending the area ratio measurement method previously reported (Image A and B). The correlation between the values by Image A and B was calculated.Results: We observed a strong linear correlation between Images A and B in the cochlear images; the Pearson's correlation coefficient (r) was 0.928 for Observer A and 0.926 for Observer B (P < 0.001, for all). A strong linear correlation was also observed in the vestibular images; the Pearson's correlation coefficient (r) was 0.962 for Observer A and 0.968 for Observer B (P < 0.001, for all).Conclusion: Measurement of endolymphatic volume after IV-SD-GBCM may be feasible using an MR imaging protocol with a reduced scan time of 8 min This method might facilitate greater use of endolymphatic hydrops imaging in clinical applications.