Sleep complaints cosegregate with illness in older adults - Clinical research informed by and informing epidemiological studies of sleep
Sleep complaints cosegregate with illness in older adults - Clinical research informed by and informing epidemiological studies of sleep
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DOI：
10.1016/s0022-3999(02)00435-x
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发表时间：
2002-07-01
影响因子：
4.7
通讯作者：
Prinz, PN
中科院分区：
文献类型：
--
作者：
Vitiello, MV;Moe, KE;Prinz, PN
目的：最近关于睡眠抱怨的流行病学研究表明，当考虑到身体和精神疾病、药物使用、药物和酒精使用等因素时，与年龄相关的睡眠抱怨患病率的增长明显低于那些没有此类控制的早期研究。为了支持这一发现，我们在两大组潜在的研究志愿者（总N=2954）中研究了临床健康筛查与睡眠抱怨和障碍之间的关系。方法：作为一项针对有阿尔茨海默病风险的老年人的研究的一部分，两组潜在的研究志愿者（n=1619和1335）分别对没有提到睡眠的广告做出了回应，并接受了三个越来越严格的健康筛查。在每个级别的筛查中，对医疗和精神健康状况及病史进行了评估，在适当的情况下，在受试者提及睡眠质量或睡眠抱怨之前，受试者被排除在进一步的研究参与之外。然后对其余受试者进行多导睡眠描记。结果：在以这种方式筛选的1619名老年志愿者中，只有51名（3.14%）被发现有明显的睡眠抱怨或障碍。以这种方式筛选的第二组1335人显示出类似的模式，只有18人（1.35%）有明显的睡眠抱怨或障碍。结论：这些发现表明，仔细的健康评估将筛选出大多数老年人的睡眠抱怨和障碍，并进一步支持流行病学证据，证明大部分老年人睡眠抱怨和障碍不是年龄本身的结果，而是与医学和精神疾病以及相关的健康负担共同分离。(C) 2002爱思唯尔科学有限公司版权所有。
Objective: The more recent epidemiological studies of sleep complaints have shown that when factors such as physical and psychiatric illness, medication use and drug and alcohol use are accounted for, the age-related increase in prevalence of sleep complaints is strikingly less than in those earlier studies without such controls. In an effort to support this finding, we examined the relationships between clinical health screenings and sleep complaints and disorders, in two large groups of potential research volunteers (total N=2954). Methods: As part of a study of older adults at risk for Alzheimer's disease, two large groups of potential research volunteers (n=1619 and 1335, respectively) replied to advertisements that made no mention of sleep and underwent three increasingly rigorous levels of health screening. At each level of screening, medical and psychiatric health and history were assessed and, where appropriate, subjects were excluded from further study participation before any mention of sleep quality or sleep complaint was made. The remaining subjects then underwent polysomnography. Results: Of 1619 elderly adult volunteers screened in this manner, only 51 (3.14%) were found to have significant sleep complaints or disorders. The second group of 1335 screened in this manner revealed a similar pattern with only 18 (1.35%) having significant sleep complaints or disorders. Conclusions: These findings indicate that careful health assessments will screen out most sleep complaints and disorders in the older population and lend further support to the epidemiological evidence demonstrating that the bulk of geriatric sleep complaints and disorders is not the result of age per se, but rather cosegregates with medical and psychiatric disorders and related health burdens. (C) 2002 Elsevier Science Inc. All rights reserved.