Increased risk for malaria in chronically malnourished children under 5 years of age in rural gambia
Increased risk for malaria in chronically malnourished children under 5 years of age in rural gambia
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DOI：
10.1093/tropej/48.2.78
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发表时间：
2002-04-01
影响因子：
2
通讯作者：
von Seidlein, L
中科院分区：
文献类型：
--
作者：
Deen, JL;Walraven, GEL;von Seidlein, L
疟疾和营养不良在撒哈拉以南非洲农村地区造成高发病率和死亡率。为了探讨营养状况与疟疾之间的关系，在一个疟疾季节，每周对一组5岁以下的冈比亚儿童进行随访。在赛季开始和结束时进行了人体测量。基线发育迟缓儿童（定义为年龄身高z评分低于-2标准差）中共有55/107（51.4%）儿童随后经历了疟疾发作，而未发育迟缓的儿童为145/380（38.2%）（RR = 1.35; 95% CI，1.08-1.69; p值= 0.01）。无论是消瘦（身高体重比z分数低于-2标准差）还是营养不良（年龄体重比z分数低于-2标准差）都不会影响对疟疾的易感性。年龄、性别和种族特征的调整并没有显著改变风险比。从疟疾季节开始到结束，疟疾对营养状况没有影响。我们的研究结果表明，长期营养不良的儿童发生疟疾的风险可能更高。
Malaria and malnutrition cause high morbidity and mortality in rural sub-Saharan Africa. To explore the relationship between nutritional status and malaria, a cohort of Gambian children under 5 years of age was followed weekly during one malaria season. Anthropometric measurements were made at the beginning and at the end of the season. A total of 55/107 (51.4 per cent) children with baseline stunting, defined as having a height-for-age z-score below -2 standard deviations, subsequently experienced malaria episodes, compared to 145/380 (38.2 per cent) children who were not stunted (RR = 1.35; 95 per cent CI, 1.08-1.69; p value = 0.01). Neither wasting (weight-for-height z-score below -2 standard deviations) nor undernutrition (weight-for-age z-score below -2 standard deviations) influenced susceptibility to malaria. Adjustment for characteristics of age, sex, and ethnicity did not significantly change the risk ratios. Malaria had no effect on the nutritional status from the beginning to the end of the malaria season. Our findings suggest that chronically malnourished children may be at higher risk for developing malaria episodes.