Respiratory phase-correlated micro-CT imaging of free-breathing rodents
Respiratory phase-correlated micro-CT imaging of free-breathing rodents
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DOI：
10.1088/0031-9155/54/12/015
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发表时间：
2009-06-21
影响因子：
3.5
通讯作者：
Kalender, Willi A.
中科院分区：
文献类型：
--
作者：
Ertel, Dirk;Kyriakou, Yiannis;Kalender, Willi A.
我们为微 CT 成像中的呼吸门控提供专用的相位相关成像程序，自动检测最佳数据窗口，从而提供最少的运动模糊。基于原始数据的运动函数（kymogram）用于同步目的和识别用于相位相关图像重建的最佳数据窗口。测量是在双源微型 CT 扫描仪上进行的。投影数据通过十次旋转获得，用于多段相位相关重建。对十个自由呼吸受试者的数据集进行了视觉评估。 kymogram 方法为相位相关图像重建提供了可靠的同步信号。此外，它还允许识别增加和减少运动的相位间隔以及最佳重建相位的相应检测。与标准图像重建相比，相位相关图像在运动模糊方面显示出显着的改进。计算出的最佳数据窗口的重建提供了最少量的运动模糊，甚至允许评估肺部的小结构。用于呼吸门控的专用回顾性相位相关图像重建程序是无运动成像的可行方法。特定于对象的最佳重建阶段可以最小化运动模糊并进一步提高图像质量。
We provide a dedicated phase-correlated imaging procedure for respiratory gating in micro-CT imaging with automatic detection of the optimal data window providing the least amount of motion blurring. A rawdata-based motion function (kymogram) was used for synchronization purposes and for identification of the optimal data window used for phase-correlated image reconstruction. Measurements were performed on a dual-source micro-CT scanner. Projection data were acquired over ten rotations for multi-segment phase-correlated reconstruction. Visual assessment was performed on datasets of ten free-breathing subjects. The kymogram approach provided a reliable synchronization signal for phase-correlated image reconstruction. Also, it allowed for the identification of phase intervals of increased and decreased motion and the corresponding detection of the optimal reconstruction phase. Phase-correlated images showed a strong improvement with respect to motion blurring compared to standard image reconstruction. A reconstruction for the calculated optimal data window provided the least amount of motion blurring and even allowed for the assessment of small structures in the lung. The dedicated retrospective phase-correlated image reconstruction procedure for respiratory gating is a feasible approach for motion-free imaging. A subject specific optimal reconstruction phase can minimize motion blurring and further improve image quality.