Differential effect of ATP binding cassette transporter A1 R219K and cholesteryl ester transfer protein TaqIB genotypes on HDL-C levels in overweight/obese and non-obese Chinese subjects
Differential effect of ATP binding cassette transporter A1 R219K and cholesteryl ester transfer protein TaqIB genotypes on HDL-C levels in overweight/obese and non-obese Chinese subjects
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DOI：
10.1080/ac.66.2.2071256
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发表时间：
2011-04-01
影响因子：
1.6
通讯作者：
Bai, Huai
中科院分区：
文献类型：
--
作者：
Huang, Yi;Wu, Yin;Bai, Huai
目的 ATP 结合盒转运蛋白 A1 (ABCA1) 和胆固醇酯转运蛋白 (CETP) 参与 HDL 代谢，并在胆固醇反向转运中发挥关键作用。本研究的目的主要是探讨ABCA1和CETP多态性与西南地区人群超重/肥胖的可能关联。 方法和结果采用PCR-RFLP分析对成都地区338名汉族人（206名超重/肥胖者和132名正常对照者）进行研究。超重/肥胖病例中ABCA1 R219K、CETP Taq IB和-629C>A多态性的基因型和等位基因频率与对照受试者相比没有显着统计学差异。然而，在对 HDL-C 水平进行分析时，与 RR 基因型携带者相比，携带 ABCA1 KK 基因型的病例在统计上显示出较高的水平，而具有 CETP B2B2 基因型的对照者的血清 HDL-C 浓度略高于 B1B1 基因型的对照者。此外，ABCA1 R219K 和 CETP Taq IB 多态性对 HDL-C 水平的联合基因型效应在对照受试者中也很明显：KK/B2B2 基因型携带者的 HDL-C 水平最高（2.23 +/- 0.91 mmol/L），而 RR/B1B1 基因型携带者的 HDL-C 水平最低（1.32 +/- 0.33）。毫摩尔/升）。 KK/B2B2 基因型受试者与其他基因型组合受试者之间的 HDL-C 水平存在显着差异（所有 P
Objectives ATP-binding cassette transporter A1 (ABCA1) and cholesteryl ester transfer protein (CETP) are involved in the HDL metabolism and play a key role in reverse cholesterol transport. The study aim was mainly to examine the possible association of the ABCA1 and CETP polymorphisms with overweight/obesity in a South-West Chinese population.Methods and results Three hundred and thirty-eight Han Chinese (206 overweight/obese and 132 normal control subjects) in Chengdu area were studied using the PCR-RFLP analysis. The genotype and allele frequencies of the ABCA1 R219K, CETP Taq IB and -629C > A polymorphisms in cases of overweight/obesity showed no significant statistical difference compared to those of the control subjects. However, on analysis of the HDL-C levels, cases showed statistically higher levels among those carrying the ABCA1 KK genotype compared to RR genotype carriers, and controls having the CETP B2B2 genotype had a marginally significantly higher serum HDL-C concentration than those of the B1B1 genotype. In addition, the combined genotype effect of the ABCA1 R219K and the CETP Taq IB polymorphisms on HDL-C levels was evident in the control subjects: the carriers of the KK/B2B2 genotype showed the highest levels of HDL-C (2.23 +/- 0.91 mmol/L), whereas those of the RR/ B1B1 genotype showed the lowest (1.32 +/- 0.33 mmol/L). There were significant differences of the HDL-C levels between subjects with genotype KK/B2B2 and those with each of the other genotype combinations (all P