Hypoglycemic activity of fermented mushroom of Coprinus comatus rich in vanadium
Hypoglycemic activity of fermented mushroom of Coprinus comatus rich in vanadium
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DOI：
10.1016/j.jtemb.2006.06.003
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发表时间：
2006-01-01
影响因子：
3.5
通讯作者：
Li, Lingjun
中科院分区：
文献类型：
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作者：
Han, Chunchao;Yuan, Junhua;Li, Lingjun
研究了富钒鸡腿菇发酵液的降血糖活性。实验采用四氧嘧啶和肾上腺素诱发的高血糖小鼠。分别测定小鼠血糖和糖化血红蛋白（HbA1c）。同时测定正常小鼠的糖耐量。灌胃CCRV后，能降低四氧嘧啶所致高血糖小鼠的血糖和HbA1c（p <0.05，p < 0.01），抑制肾上腺素所致的血糖Ascension（p <0.01），提高正常小鼠的糖耐量。此外，四氧嘧啶诱导的高血糖小鼠的体重逐渐增加。在鸡腿菇发酵过程中，低剂量的钒与鸡腿菇联合作用。comatus，诱导高血糖小鼠的血糖和HbA1c水平显著降低。(c)2006年Elsevier GmbH。All rights reserved.
The hypoglycemic activity of fermented mushroom of Coprinus comatus rich in vanadium (CCRV) was studied in this paper. Alloxan and adrenalin induced hyperglycemic mice were used in the study. The blood glucose and the HbA1c of the mice were analyzed, respectively. At the same time, the sugar tolerance of the normal mice was also determined. After the mice were administered (ig) with CCRV, the blood glucose and the HbA1c of alloxan-induced hyperglycemic mice decreased (p < 0.05, p < 0.01), ascension of blood glucose induced by adrenalin was inhibited (p < 0.01) and the sugar tolerance of the normal mice was improved. Also, the body weight of the alloxan-induced hyperglycemic mice was increased gradually. In the fermented mushroom of C comatus, vanadium at lower doses in combination with C. comatus, induced significant decreases of the blood glucose and HbA1c levels in hyperglycemic mice. (c) 2006 Elsevier GmbH. All rights reserved.