Brief review on repurposed drugs and vaccines for possible treatment of COVID-19.
Brief review on repurposed drugs and vaccines for possible treatment of COVID-19.
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DOI：
10.1016/j.ejphar.2021.173977
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发表时间：
2021-05-05
影响因子：
5
通讯作者：
Mazumder N
中科院分区：
文献类型：
--
作者：
De P;Chakraborty I;Karna B;Mazumder N
严重急性呼吸系统综合征冠状病毒2型（SARS-CoV-2）是2019年冠状病毒病（Covid-19）的病原体，已夺去100多万人的生命。正在进行各种计算机模拟、体外和体内研究，以了解SARS-CoV-2对人类细胞代谢的影响以及可能使用的各种药物和药物靶点。在这篇综述中，我们讨论了病毒和人类蛋白质之间的蛋白质-蛋白质相互作用（PPI），以及病毒的目标，如蛋白酶。我们试图了解各种针对SARS-CoV-2的再利用抗病毒药物的分子机制，它们的联合治疗，药物剂量方案，以及它们的不良反应沿着可能的替代品，如无毒的抗病毒植物化学物质。最终，需要随机对照试验来确定这些化合物中的哪一种具有所需的疗效和安全性平衡。我们还关注世界各地为对抗Covid-19而开发的诊断方法和候选疫苗的最新进展。
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of the pandemic coronavirus disease 2019 (Covid-19) has claimed more than a million lives. Various in silico, in vitro, and in vivo studies are being conducted to understand the effect of SARS-CoV-2 on the cellular metabolism of humans and the various drugs and drug-targets that may be used. In this review, we discuss protein-protein interactions (PPIs) between viral and human proteins as well as viral targets like proteases. We try to understand the molecular mechanism of various repurposed antiviral drugs against SARS-CoV-2, their combination therapies, drug dosage regimens, and their adverse effects along with possible alternatives like non-toxic antiviral phytochemicals. Ultimately, randomized controlled trials are needed to identify which of these compounds has the required balance of efficacy and safety. We also focus on the recent advancements in diagnostic methods and vaccine candidates developed around the world to fight against Covid-19.
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