Skin Microbiome Compositional Changes in Atopic Dermatitis Accompany Dead Sea Climatotherapy
Skin Microbiome Compositional Changes in Atopic Dermatitis Accompany Dead Sea Climatotherapy
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DOI：
10.1111/php.13119
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发表时间：
2019-07-10
影响因子：
3.3
通讯作者：
Meshner, Shiri
中科院分区：
文献类型：
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作者：
Brandwein, Michael;Fuks, Garold;Meshner, Shiri
死海气候疗法 (DSC) 是一种行之有效的治疗方法，可用于治疗多种疾病，包括特应性皮炎。皮肤微生物组研究表明，皮肤微生物组多样性与特应性皮炎的严重程度和并发的金黄色葡萄球菌过度生长呈反相关。本研究旨在确定 DSC 是否会引起皮肤微生物组变化，同时导致特应性皮炎的临床改善。我们对 35 名特应性皮炎患者和 10 名健康对照者的肘前窝和腘窝进行了采样。通过对 16S rRNA 基因的多个区域进行测序，获得了高分辨率微生物群落分析。在病变和非病变部位均观察到生态失调，治疗后部分减弱。严重AD皮肤经历了最显着的群落变化，表皮葡萄球菌、轻链球菌和藤黄微球菌的相对丰度受到死海气候疗法的显着影响。我们的研究强调了死海气候疗法引起的 AD 皮肤微生物群的时间变化，并为气候疗法成功治疗包括 AD 在内的多种皮肤病提供了可能的解释。
Dead Sea climatotherapy (DSC) is a well-established therapeutic modality for the treatment of several diseases, including atopic dermatitis. Skin microbiome studies have shown that skin microbiome diversity is anticorrelated with both atopic dermatitis severity and concurrent Staphylococcus aureus overgrowth. This study aimed to determine whether DSC induces skin microbiome changes concurrent with clinical improvements in atopic dermatitis. We sampled 35 atopic dermatitis patients and ten healthy controls on both the antecubital and popliteal fossa. High-resolution microbial community profiling was attained by sequencing multiple regions of the 16S rRNA gene. Dysbiosis was observed in both lesional and nonlesional sites, which was partially attenuated following treatment. Severe AD skin underwent the most significant community shifts, and Staphylococcus epidermidis, Streptococcus mitis and Micrococcus luteus relative abundance were significantly affected by Dead Sea climatotherapy. Our study highlights the temporal shifts of the AD skin microbiome induced by Dead Sea climatotherapy and offers potential explanations for the success of climatotherapy on a variety of skin diseases, including AD.