Follicular localization of dendritic cells in a xanthomatous inflammatory tumor of lung associated with human herpes virus-8 infection
Follicular localization of dendritic cells in a xanthomatous inflammatory tumor of lung associated with human herpes virus-8 infection
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DOI：
10.1007/s00428-006-0318-y
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发表时间：
2006-12-01
期刊：
影响因子：
3.5
通讯作者：
Kradin, R. L.
中科院分区：
文献类型：
--
作者：
Farris, A. B., III;Kradin, R. L.
一名17岁的男子接受化疗和放射治疗结节硬化性霍奇金淋巴瘤，提出了一个左胸壁肿块。10年后，一个左上叶肺肿瘤被确定。肿瘤切除显示1.3 cm黄色肺结节，由上皮样和梭形脂质负载的CD 68+和因子XIIIa+巨噬细胞组成。具有CD 1a、肌成束蛋白和ALK-1阳性树突状细胞的明显滤泡结构，并且基本上缺乏胞浆内脂质是病变的显著特征。大多数黄色瘤样巨噬细胞表达人类疱疹病毒-8抗原。目前世界卫生组织分类的“炎性肌纤维母细胞瘤”进行检查，并与免疫缺陷状态和机会性感染的“炎性假瘤”的一个子集的关联进行了讨论。
A 17-year-old man was treated with chemotherapy and radiation for nodular sclerosing Hodgkin lymphoma that presented as a left chest wall mass. Ten years later, a left upper lobe lung tumor was identified. The tumor resection demonstrated a 1.3-cm yellow lung nodule composed of epithelioid and spindled lipid-laden CD68+ and Factor XIIIa+ macrophages. Distinct follicular structures with dendritic cells positive for CD1a, fascin, and ALK-1 and largely devoid of intracytoplasmic lipid were a distinguishing feature of the lesion. Most of the xanthomatous macrophages expressed human herpes virus-8 antigen. The current World Health Organization classification of "inflammatory myofibroblastic tumors" is examined, and the association of a subset of "inflammatory pseudotumors" with immunodeficiency states and opportunistic infection is discussed.