TiO2 nanoparticles negatively impact the bioavailability and antioxidant activity of tea polyphenols
TiO2 nanoparticles negatively impact the bioavailability and antioxidant activity of tea polyphenols
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TiO2 纳米粒子对茶多酚的生物利用度和抗氧化活性产生负面影响
DOI：
10.1016/j.foodchem.2021.131045
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发表时间：
2021-09-29
期刊：
影响因子：
8.8
通讯作者：
Shi, Jinglan
中科院分区：
文献类型：
--
作者：
Li, Qian;Liu, Lu;Shi, Jinglan
本研究通过体外消化模型研究TiO2纳米颗粒（NPs）对共摄茶多酚提取物的稳定性、生物利用度和抗氧化活性的影响。添加0.5% (w/w) TiO2 NPs后，茶多酚含量显著降低。没食子儿茶素没食子酸酯水平下降幅度最大，从101.9 μ g/mL降至27.2 μ g/mL，降幅约为73.3%。TiO2 NP还以剂量依赖的方式降低了茶多酚的生物利用度，这是由于形成了大的多酚-TiO2 NP复合物聚集体，不能通过用于模拟肠壁的透析管中的孔。此外，TiO2 NPs降低了模拟胃肠道内茶多酚的抗氧化活性。综上所述，我们的研究结果表明，高水平的TiO2 NPs（但在许多国家目前的法律限制范围内）可能会对食品中多酚的生物利用度和生物活性产生负面影响。
This study was to investigate the influence of TiO2 nanoparticles (NPs) on the stability, bioavailability, and antioxidant activity of co-ingested tea polyphenols extract using an in vitro digestion model. The tea polyphenol contents decreased significantly after addition of 0.5 % (w/w) TiO2 NPs. The gallocatechin gallate level decreased the most, changing from 101.9 to 27.2 mu g/mL (about 73.3%). The TiO2 NPs also reduced the bioavailability of the tea polyphenols in a dose-dependent manner, which was ascribed to the formation of large polyphenol-TiO2 NP complex aggregates that could not pass through the pores in the dialysis tube used to simulate the gut wall. Additionally, the TiO2 NPs decreased the antioxidant activity of the tea polyphenols within the simulated gastrointestinal tract. In summary, our results show that high levels of TiO2 NPs (but within the current legal limits in many countries) may negatively impact the bioavailability and bioactivity of polyphenols in foods.