Potential detrimental effects of a phytoestrogen-rich diet on male fertility in mice
Potential detrimental effects of a phytoestrogen-rich diet on male fertility in mice
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DOI：
10.1016/j.mce.2010.02.011
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发表时间：
2010-06-10
影响因子：
4.1
通讯作者：
Nefa, Serge
中科院分区：
文献类型：
--
作者：
Cederroth, Christopher R.;Zimmermann, Celine;Nefa, Serge
Soy and soy-based products are widely consumed by infants and adult individuals. There has been speculation that the presence of isoflavone phytoestrogens in soybean cause adverse effects on the development and function of the male reproductive system The purpose of this study was to examine the influence of dietary soy and phytoestrogens on testicular and reproductive functions. Male mice were fed from conception to adulthood with either a high soy-containing diet or a soy-free diet. Although adult mice fed a soy-rich diet exhibited normal male behaviour and were fertile, we observed a reduced proportion of haploid germ cells in testes correlating with a 25% decrease in epididymal sperm counts and a 21% reduction in litter size LH and androgens levels were not affected but transcripts coding for androgen-response genes in Sertoli cells and Gapd-s, a germ cell-specific gene involved in sperm glycolysis and mobility were significantly reduced In addition, we found that dietary soy decreased the size of the seminal vesicle but without affecting its proteolytic activity. Taken together, these studies show that long-term exposure to dietary soy and phytoestrogens may affect male reproductive function resulting in a small decrease in sperm count and fertility (C) 2010 Elsevier Ireland Ltd. All rights reserved.
