Targeting Polycomb systems to regulate gene expression: modifications to a complex story.
Targeting Polycomb systems to regulate gene expression: modifications to a complex story.
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DOI：
10.1038/nrm4067
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发表时间：
2015-11
期刊：
影响因子：
--
通讯作者：
Klose RJ
中科院分区：
文献类型：
--
作者：
Blackledge NP;Rose NR;Klose RJ
多梳族蛋白是发育过程中正常基因调控所必需的转录抑制因子。最近的研究表明，polycomb抑制复合物识别和招募通过一系列不同的机制，其中涉及转录因子，CpG岛元件和非编码RNA。再加上认识到polycomb抑制复合物1（PRC1）和2（PRC2）之间的相互作用比以前认识到的更复杂，这增加了我们在分子水平上对脊椎动物polycomb系统的理解。
Polycomb group proteins are transcriptional repressors that are essential for normal gene regulation during development. Recent studies suggest that polycomb repressive complexes recognise and are recruited to through a range of different mechanisms, which involve transcription factors, CpG island elements and non-coding RNAs. Together with the realization that the interplay between polycomb repressive complexes 1 (PRC1) and 2 (PRC2) is more intricate than previously appreciated, this has increased our understanding of the vertebrate polycomb system at the molecular level.