DYNAMICS OF BETA-CELL MASS IN THE GROWING RAT PANCREAS - ESTIMATION WITH A SIMPLE MATHEMATICAL-MODEL
DYNAMICS OF BETA-CELL MASS IN THE GROWING RAT PANCREAS - ESTIMATION WITH A SIMPLE MATHEMATICAL-MODEL
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DOI：
10.2337/diabetes.44.3.249
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发表时间：
1995-03-01
期刊：
影响因子：
7.7
通讯作者：
BONNERWEIR, S
中科院分区：
文献类型：
--
作者：
FINEGOOD, DT;SCAGLIA, L;BONNERWEIR, S
内分泌胰腺的生长和发育已经研究了很多年，但在正常生长的胰腺以及糖尿病发病过程中，关于产生胰岛素的β细胞数量的调节仍存在问题。在正常和病理生理条件下，β细胞数量的稳态控制基于细胞增殖、细胞生长和细胞死亡之间的平衡。为了深入了解这些动态过程各自的相对贡献，我们首先对正常斯普拉格 - 道利（Sprague - Dawley）大鼠不同年龄阶段维持β细胞数量所涉及的各成分（包括复制率、β细胞体积以及β细胞数量本身）的现有数据进行了数学分析。然后将这些数据整合到一个简单的质量平衡方程中，构建了正常生长的大鼠胰腺中β细胞数量动态的数学模型。这样一个模型使我们能够推断出无法测量的通量（即新生和细胞死亡）对已知的β细胞数量的贡献。该模型的另一个重要贡献是提出了关于内分泌胰腺中细胞死亡和细胞更新平衡控制的未解决问题。
The growth and development of the endocrine pancreas has been studied for many years, but questions remain concerning the regulation of the mass of insulin-producing beta-cells both in the normal growing pancreas and during the pathogenesis of diabetes, The homeostatic control of beta-cell mass in both normal and pathophysiological conditions is based on the balance of cell proliferation, cell growth, and cell death, To gain insight into the relative contribution of each of these dynamic processes, we first mathematically analyzed the data available on the components involved in the maintenance of beta-cell mass, including rates of replication, beta-cell volume, and the beta-cell mass itself, at various ages in normal Sprague-Dawley rats. Then these data were combined in a simple mass balance equation to construct a mathematical model of the dynamics of the beta-cell mass in the normal growing rat pancreas, Such a model has allowed us to infer the contributions of fluxes that cannot be measured, i.e., neogenesis and cell death, to the known mass of beta-cells. Another important contribution of this model is to raise unanswered questions concerning the control of the balance of cell death and cell renewal in the endocrine pancreas.