Association of serum sialic acid concentration with diabetic complications and cardiovascular risk factors in an Indian population.
Association of serum sialic acid concentration with diabetic complications and cardiovascular risk factors in an Indian population.
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DOI：
10.5114/amsad.2021.105142
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Verma R
中科院分区：
文献类型：
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作者：
Bansal P;Bansal P;Verma R
唾液酸（SA）是神经氨酸的乙酰化产物。作为许多细胞表面受体（如胰岛素受体）的辅因子，与大多数血清急性期反应物呈正相关。唾液酸是血清的重要成分，在糖尿病和某些恶性肿瘤等疾病中升高。糖尿病（DM）与SA浓度增加以及其他并发症沿着有关。本研究旨在探讨血清SA与2型糖尿病的关系。共有200例2型糖尿病患者，145例男性和55例女性，被纳入研究。另取100名健康人作为对照组。评估的参数包括血清SA、血脂、尿微量白蛋白、LDL-C、脂蛋白（a）和血清纤维蛋白原。血清SA和糖尿病并发症，即视网膜病变，肾病，神经病变之间的关系也进行了评估。2型DM患者SA水平（77.35 ±4.6 mg%）显著高于对照组（68.23 ±7.9 mg%）（p < 0.01）。糖尿病肾病和视网膜病变患者血清SA水平升高。血清SA与糖尿病神经病变之间无相关性。血清SA浓度升高与2型DM和相关心血管危险因素显着相关。因此，进一步研究急性期反应标志物和介质作为糖尿病微血管并发症的指标或预测因子是合理的。
Sialic acid (SA) is an acetylated product of neuraminic acid. It acts as a cofactor of many cell surface receptors (e.g. insulin receptors) and is positively associated with most of the serum acute phase reactants. Sialic acid is an important component of serum, which is elevated in diseases such as diabetes and certain malignancies. Diabetes mellitus (DM) is associated with an increase in SA concentration along with other complications. The present study was undertaken to assess the relationship between serum SA and type 2 diabetes. A total of 200 type 2 DM patients, 145 males and 55 females, were included in the study. Also, 100 healthy individuals served as the control group. Parameters assessed included serum SA, lipid profile, urine microalbumin, LDL-C, lipoprotein(a), and serum fibrinogen. The relationship between serum SA and diabetic complications viz retinopathy, nephropathy, and neuropathy was also assessed. Type 2 DM patients had significantly higher levels (p < 0.01) of SA (77.35 ±4.6 mg%) as compared to the control group (68.23 ±7.9 mg%). Increased levels of serum SA were seen in patients with diabetic nephropathy and retinopathy. No correlation was seen between serum SA and diabetic neuropathy. Elevated serum SA concentration is significantly related to type 2 DM and associated cardiovascular risk factors. Further study of acute-phase response markers and mediators as indicators or predictors of diabetic microvascular complications is therefore justified.