MODEL STUDIES ON DISTRIBUTION OF BLOOD-CELLS AT MICROVASCULAR BIFURCATIONS
MODEL STUDIES ON DISTRIBUTION OF BLOOD-CELLS AT MICROVASCULAR BIFURCATIONS
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DOI：
10.1152/ajpheart.1985.248.4.h568
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发表时间：
1985-01-01
影响因子：
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通讯作者：
SCHMIDSCHONBEIN, GW
中科院分区：
文献类型：
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作者：
CHIEN, S;TVETENSTRAND, CD;SCHMIDSCHONBEIN, GW
为了模拟微血管分支点处白色和红细胞的流动行为，研究了低雷诺数（0.01-0.1）流动下对称T分支处中性浮力球形和盘形颗粒的分布。颗粒分布由到达子分支的部分颗粒通量表示，作为到达相同分支的部分体积总体流量的函数。研究了球形颗粒的颗粒与管直径比为0.32-0.79，圆盘的颗粒与管直径比为0.4-0.8。当颗粒尺寸接近管道尺寸时，颗粒通量与体积流量之间的关系由单位斜率的线性关系变为非线性的S形曲线。测量分流器的入口处的分叉和偏心分布的球体和磁盘被用来开发一个模型，允许预测所观察到的颗粒分布。这些结果可用于解释白色和红细胞在尺寸接近细胞大小的微血管分叉中的分布。
To model the flow behavior of white and red blood cells at microvascular branch points, the distribution of neutrally buoyant spherical and disk-shaped particles at a symmetric T bifurcation was investigated for low Reynolds number flows (0.01-0.1). The particle distribution was represented by fractional particle flux to a daughter branch as a function of the fractional volumetric bulk flow to the same branch. Particle-to-tube diameter ratios of 0.32-0.79 were studied for the spherical particles and 0.4-0.8 for the disks. As the particle dimensions approach that of the tube, the relation between the fractional particle flux and fractional bulk flow changes from a linear relation of unity slope to a nonlinear S-shaped curve. Measurements of the flow divider at the entrance to the bifurcation and the eccentricity distributions for the spheres and disks were used to develop a model that permits prediction of the observed particle distributions. These results can be used to interpret the distribution of white and red blood cells in microvascular bifurcations with dimensions close to the cell size.