OPINION Myocardial edema-a new clinical entity?
OPINION Myocardial edema-a new clinical entity?
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DOI：
10.1038/nrcardio.2010.28
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发表时间：
2010-05-01
影响因子：
49.6
通讯作者：
Friedrich, Matthias G.
中科院分区：
文献类型：
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作者：
Friedrich, Matthias G.
水肿是组织对急性损伤反应的一般组成部分，因此是评估体内组织损伤严重程度的重要诊断目标。在过去，水肿不能被用作诊断目标，因为即使是组织学技术也不能提供关于其存在、程度和区域分布的可靠定性甚至定量数据。心脏MRI即将改变这一点。使用水敏MRI，可以在几次屏气内可视化体内心肌水肿，而无需使用辐射或造影剂。水肿成像在与疑似急性心肌损伤相关的各种临床环境中提供有用的增量诊断和预后信息。结合瘢痕成像，MRI可区分可逆性和不可逆性损伤，并可量化冠状动脉血运重建后的心肌挽救。由于这种独特的贡献，水肿MRI应被视为一种重要的诊断工具，作为多靶点MRI扫描的一部分，说明了全面心脏MRI在安全有效地诊断和分期心肌疾病方面的特殊作用。
Edema is a generic component of the tissue response to acute injury and, therefore, an important diagnostic target for assessing the acuity of tissue damage in vivo. In the past, edema could not be used as a diagnostic target, because even histological techniques failed to provide reliable qualitative or even quantitative data on its presence, extent, and regional distribution. Cardiac MRI is about to change that. Using water-sensitive MRI, visualization of myocardial edema in vivo is possible within a few breath holds, without using radiation or contrast agents. Edema imaging provides useful incremental diagnostic and prognostic information in a variety of clinical settings associated with suspected acute myocardial injury. In combination with scar imaging, MRI differentiates reversible from irreversible injury and can quantify myocardial salvage after coronary revascularization. With this unique contribution, MRI of edema should be considered an essential diagnostic tool and, as part of a multitarget MRI scan, illustrates the exceptional role of comprehensive cardiac MRI in diagnosing and staging myocardial diseases safely and efficiently.