Corticotropin-releasing hormone is not the sole factor mediating exercise-induced adrenocorticotropin release in humans.
Corticotropin-releasing hormone is not the sole factor mediating exercise-induced adrenocorticotropin release in humans.
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促肾上腺皮质激素释放激素并不是介导人类运动引起的促肾上腺皮质激素释放的唯一因素。
DOI：
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发表时间：
1991
影响因子：
5.8
通讯作者：
George C. Chrousos
中科院分区：
文献类型：
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作者：
Bonnie Smoak;Patricia Deuster;Douglas Rabin;George C. Chrousos
为了确定 CRH 是否是运动期间 ACTH 释放的唯一调节剂，五名男性和五名女性在单独访视时以受试者盲法随机方式接受了 6 小时的绵羊 CRH（1 微克/kg.h）输注和作为安慰剂的盐水输注。每次输注第四个小时后，当绵羊 CRH 血浆浓度充分升高，使促肾上腺皮质激素对 CRH 进一步反应的能力饱和时，每个受试者都完成了高强度间歇跑步。 CRH输注期间血浆ACTH和皮质醇水平显着增加，分别从4.6 +/- 0.8（平均值+/- SE）至8.6 +/- 1.6 pmol/L和从361 +/- 39至662 +/- 70 nmol/L（P小于0.05）。尽管 CRH 输注期间运动前皮质醇水平升高，但运动后血浆 ACTH 升至 32.0 +/- 8.5 pmol/L。在输注盐水期间，血浆ACTH从运动前的3.4+/-0.6pmol/L上升至运动后的18.1+/-4.2。 CRH 输注期间运动后 ACTH 和皮质醇值的时间积分反应高于盐水输注期间（P 小于 0.05）。两项测试之间没有观察到运动引起的心率或乳酸、肾上腺素和去甲肾上腺素血浆浓度的显着差异。研究结果表明，除了 CRH 之外，还有一些因素会导致运动期间 ACTH 释放。由下丘脑的大细胞和/或小细胞神经元产生的加压素是可能的候选者。
To determine whether CRH is the sole mediator of ACTH release during exercise, five men and five women were given, in a subject-blinded random manner at separate visits, both a 6-h infusion of ovine CRH (1 microgram/kg.h) and a saline infusion as a placebo. After the fourth hour of each infusion, when plasma concentrations of ovine CRH were sufficiently elevated to saturate the capacity of the corticotroph to respond further to CRH, each subject completed a high intensity intermittent run. Plasma ACTH and cortisol levels increased significantly during the CRH infusion from 4.6 +/- 0.8 (mean +/- SE) to 8.6 +/- 1.6 pmol/L and from 361 +/- 39 to 662 +/- 70 nmol/L, respectively (P less than 0.05). Despite elevated preexercise cortisol levels during the CRH infusion, plasma ACTH rose to 32.0 +/- 8.5 pmol/L after exercise. During the saline infusion, plasma ACTH rose from 3.4 +/- 0.6 pmol/L before exercise to 18.1 +/- 4.2 after exercise. Time-integrated responses for postexercise values of ACTH and cortisol were higher during the CRH infusion than during the saline infusion (P less than 0.05). No significant exercise-induced differences in heart rate or plasma concentrations of lactate, epinephrine, and norepinephrine were observed between the two tests. The findings suggest that some factor(s) in addition to CRH causes ACTH release during exercise. Vasopressin, produced by the magnocellular and/or parvocellular neurons of the hypothalamus, is a likely candidate.