Regression of fundic gland polyps following acquisition of Helicobacter pylori
Regression of fundic gland polyps following acquisition of Helicobacter pylori
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DOI：
10.1136/gut.51.5.742
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发表时间：
2002-11-01
期刊：
影响因子：
24.5
通讯作者：
Chiba, T
中科院分区：
文献类型：
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作者：
Watanabe, N;Seno, H;Chiba, T
胃底腺息肉（FGPs）患者幽门螺杆菌感染的患病率非常低。我们在此报告两个病例与多个fgp，在新的幽门螺杆菌获得后回归。1、2号患者在正常的基底粘膜中有多个fgp，无炎症改变或萎缩。两人都没有感染幽门螺杆菌。然而，在感染幽门螺杆菌后，除了患者1的一个FGP外，两例患者的所有FGP都完全消失了。尽管患者1的剩余息肉在幽门螺杆菌感染后体积大大减小，但在根除后又再次增大。有趣的是，在剩余的息肉中，我们发现了激活β -连环蛋白基因突变，而在患者II的fgp中没有检测到这种突变。因此，幽门螺杆菌感染可能对fgp的发展有抑制作用。
The prevalence of Helicobacter pylori infection is very low in patients with fundic gland polyps (FGPs) of the stomach. We report here two cases with multiple FGPs that regressed following new H pylori acquisition. Patient Nos I and II had multiple FGPs in normal fundic mucosa without inflammatory changes or atrophy. Both were not infected with H pylori. Following acquisition of H pylori infection however, all FGPs in both patients completely disappeared except for one FGP in patient No I. Although the size of the remaining polyp in patient No I was greatly reduced after H pylori acquisition, it became enlarged again after eradication. Interestingly, in the remaining polyp, we found an activating beta-catenin gene mutation whereas no such mutations were detected in FGPs of patient No II. Thus H pylori infection may have an inhibitory effect on the development of FGPs.