Acid-sensing ion channel (ASIC) 1a undergoes a height transition in response to acidification.
Acid-sensing ion channel (ASIC) 1a undergoes a height transition in response to acidification.
复制标题
酸敏感离子通道 (ASIC) 1a 因酸化而发生高度转变。
DOI：
10.1016/j.febslet.2010.05.050
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发表时间：
2010
期刊：
影响因子：
3.5
通讯作者：
Yokokawa M
中科院分区：
文献类型：
--
作者：
Yokokawa M
The acid-sensing ion channel (ASIC) 1a is known to assemble as a homotrimer. Here, we used atomic force microscopy to image ASIC1a, integrated into lipid bilayers, at pH 7.0 and pH 6.0. The triangular appearance of the channel was clearly visible. A height distribution for the channels at pH 7.0 had two peaks, at 2 and 4nm, likely representing the intracellular and extracellular domains, respectively. At pH 6.0 the 2-nm peak remained, but the higher peak shifted to 6nm. Hence, the extracellular domain of the channel becomes ‘taller’ after acidification.
