Ephs and ephrins in cancer: ephrin-A1 signalling.
Ephs and ephrins in cancer: ephrin-A1 signalling.
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DOI：
10.1016/j.semcdb.2011.10.019
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发表时间：
2012-02
影响因子：
7.3
通讯作者：
Debinski, Waldemar
中科院分区：
文献类型：
--
作者：
Beauchamp, Amanda;Debinski, Waldemar
Ephrin-A1及其主要受体EphA 2参与了许多生理过程，并因其在恶性肿瘤中的作用而受到广泛研究。肝配蛋白-Eph信号传导本身是复杂的，并且也是细胞类型依赖性的，使得阐明肝配蛋白-A1在肿瘤形成中的确切作用具有挑战性。多种致癌信号传导途径，如MAP/ERK和PI 3 K受肝配蛋白-A1的影响，在某些情况下，证据表明在一种细胞或癌症类型中促进特定途径，而在另一种类型的细胞或癌症中抑制相同途径。EphrinA 1还在血管生成和肿瘤新血管形成中发挥不可或缺的作用。直到最近，研究肝配蛋白的研究集中在配体作为GPI锚定蛋白，需要膜锚定或人工聚集Eph受体激活。然而，最近的研究已经证明了可溶性单体肝配蛋白A1的功能作用。这篇评论将集中在人类恶性肿瘤的肝配蛋白A1特异性信号的各种形式。
Ephrin-A1 and its primary receptor, EphA2, are involved in numerous physiological processes and have been intensely studied for their roles in malignancy. Ephrin-Eph signalling is complex on its own and is also cell-type dependent, making elucidation of the exact role of ephrin-A1 in neoplasia challenging. Multiple oncogenic signalling pathways, such as MAP/ERK and PI3K are affected by ephrin-A1, and in some cases evidence suggests the promotion of a specific pathway in one cell or cancer type and inhibition of the same pathway in another type of cell or cancer. EphrinA1 also plays an integral role in angiogenesis and tumor neovascularization. Until recently, studies investigating ephrins focused on the ligands as GPI-anchored proteins that required membrane anchoring or artificial clustering for Eph receptor activation. However, recent studies have demonstrated a functional role for soluble, monomeric ephrin-A1. This review will focus on various forms of ephrin-A1-specific signalling in human malignancy.
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