Impaired consciousness in epilepsy.
Impaired consciousness in epilepsy.
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DOI：
10.1016/s1474-4422(12)70188-6
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发表时间：
2012-09
期刊：
影响因子：
--
通讯作者：
Blumenfeld H
中科院分区：
文献类型：
--
作者：
Blumenfeld H
意识对正常的人类生活至关重要。在癫痫发作意识往往是短暂的丧失，使其无法为个人的经验或作出反应。这对安全、生产力、情绪健康和生活质量都有巨大的影响。为了预防癫痫意识障碍，有必要了解癫痫发作期间导致脑功能障碍的机制。正常情况下，“意识系统”--一套专门的皮层-皮层下结构--维持警觉、注意力和意识。神经影像学、电生理学和前瞻性行为测试的最新进展为癫痫发作如何破坏意识系统提供了新的线索。包括失神、全身强直阵挛和复杂部分性癫痫发作在内的多种癫痫发作类型通过不同的机制聚集在同一组解剖结构上以扰乱意识。了解这些机制可能会导致改善治疗策略，以防止意识障碍和改善癫痫患者的生活质量。
Consciousness is essential to normal human life. In epileptic seizures consciousness is often transiently lost making it impossible for the individual to experience or respond. This has huge consequences for safety, productivity, emotional health and quality of life. To prevent impaired consciousness in epilepsy it is necessary to understand the mechanisms leading to brain dysfunction during seizures. Normally the “consciousness system”—a specialized set of cortical-subcortical structures—maintains alertness, attention and awareness. Recent advances in neuroimaging, electrophysiology and prospective behavioral testing have shed new light on how epileptic seizures disrupt the consciousness system. Diverse seizure types including absence, generalized tonic-clonic and complex partial seizures converge on the same set of anatomical structures through different mechanisms to disrupt consciousness. Understanding these mechanisms may lead to improved treatment strategies to prevent impaired consciousness and improve quality of life in people with epilepsy.