Elevated risk of carrying gentamicin-resistant Escherichia coli among U.S. poultry workers.
Elevated risk of carrying gentamicin-resistant Escherichia coli among U.S. poultry workers.
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DOI：
10.1289/ehp.10191
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发表时间：
2007-12
影响因子：
10.4
通讯作者：
Silbergeld, Ellen
中科院分区：
文献类型：
--
作者：
Price, Lance B;Graham, Jay P;Lackey, Leila G;Roess, Amira;Vailes, Rocio;Silbergeld, Ellen
食品动物生产中的抗菌剂使用是一个日益受到关注的问题。在肉鸡生产中用于治疗、预防和促进生长的抗菌剂的应用与耐抗菌剂肠道细菌的出现和传播有关。虽然人类通过食物暴露于抗菌素耐药性细菌已被广泛研究，但很少关注职业和环境暴露途径。我们的目的是测量与社区参考相比，家禽工人中耐抗生素大肠杆菌定植的相对风险。我们从马里兰州和弗吉尼亚州的Delmarva地区的16名家禽工人和33名社区居民中收集粪便样本和健康调查。E.从粪便标本中培养大肠埃希菌，并测定每株大肠埃希菌对氨苄西林、环丙沙星、头孢曲松、庆大霉素、呋喃妥因和四环素的敏感性。大肠杆菌分离株。我们估计了携带耐药大肠杆菌的相对风险。与社区参考相比，家禽业工人中的大肠杆菌。家禽饲养工人携带耐庆大霉素大肠杆菌的几率是普通工人的32倍。大肠杆菌与社区参考相比。家禽业工人携带多重耐药大肠杆菌的风险也显著增加。杆菌耐药大肠杆菌的职业暴露。在肉鸡生产中，来自活动物接触的大肠杆菌可能是耐抗生素大肠杆菌进入的重要途径。进入社区。
Antimicrobial use in food-animal production is an issue of growing concern. The application of antimicrobials for therapy, prophylaxis, and growth promotion in broiler chicken production has been associated with the emergence and dissemination of antimicrobial-resistant enteric bacteria. Although human exposure to antimicrobial-resistant bacteria through food has been examined extensively, little attention has been paid to occupational and environmental pathways of exposure. Our objective was to measure the relative risk for colonization with antimicrobial-resistant Escherichia coli among poultry workers compared with community referents. We collected stool samples and health surveys from 16 poultry workers and 33 community referents in the Delmarva region of Maryland and Virginia. E. coli was cultured from stool samples, and susceptibility to ampicillin, ciprofloxacin, ceftriaxone, gentamicin, nitrofurantoin, and tetracycline was determined for each E. coli isolate. We estimated the relative risk for carrying antimicrobial-resistant E. coli among poultry workers compared with community referents. Poultry workers had 32 times the odds of carrying gentamicin-resistant E. coli compared with community referents. The poultry workers were also at significantly increased risk of carrying multidrug-resistant E. coli. Occupational exposure to antimicrobial-resistant E. coli from live-animal contact in the broiler chicken industry may be an important route of entry for antimicrobial-resistant E. coli into the community.