Vimentin and glial fibrillary acidic protein in human brain tumors.
Vimentin and glial fibrillary acidic protein in human brain tumors.
复制标题
人脑肿瘤中的波形蛋白和神经胶质纤维酸性蛋白。
DOI：
10.1007/bf00165169
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发表时间：
1985
影响因子：
3.9
通讯作者：
Borit,A
中科院分区：
文献类型：
--
作者：
Yung,WK;Luna,M;Borit,A
应用过氧化物酶-抗过氧化物酶(PAP)技术，检测了35例原发性脑肿瘤组织中波形蛋白和GFAP的表达。低级别和高级别星形细胞瘤均含有Vimentin和GFAP阳性细胞。室管膜瘤也对这两种标记物进行染色。在胶质肉瘤中，胶质母细胞瘤部分呈星形细胞瘤染色，而纤维肉瘤部分仅见波形蛋白染色。髓母细胞瘤和少突胶质细胞瘤的波形蛋白和GFAP均为阴性，而脑膜瘤中有散在的波形蛋白阳性细胞。这些结果表明，Vimentin和GFAP的表达主要局限于胶质源性肿瘤，Vimentin有可能成为区分未分化的GFAP阴性的胶质瘤和间叶性肿瘤与原始神经外胚层肿瘤的有用标记物。
Using the peroxidase-antiperoxidase (PAP) technique, we examined 35 primary brain tumors for expression of vimentin and GFAP. Both low-grade and high-grade astrocytomas contained vimentin-positive and GFAP-positive cells. Ependymomas also stained for both markers. In gliosarcomas, the glioblastomatous portions stained like astrocytomas, while only vimentin stain was seen in the fibrosarcomatous portions. Medulloblastomas and oligodendrogliomas were negative for both vimentin and GFAP, while meningiomas contained scattered areas of vimentin-positive cells. These results suggest that the expression of vimentin and GFAP is mostly confined to glial-derived tumors, and that vimentin can potentially be a useful marker for distinguishing undifferentiated GFAP-negative glial tumors and mesenchymal tumors from primitive neuroectodermal tumors.