Bioactive daphnane diterpenes from Wikstroemia chuii with their potential anti-inflammatory effects and anti-HIV activities
Bioactive daphnane diterpenes from Wikstroemia chuii with their potential anti-inflammatory effects and anti-HIV activities
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来自 Wikstroemia chuii 的生物活性瑞香二萜具有潜在的抗炎作用和抗 HIV 活性
DOI：
10.1016/j.bioorg.2020.104388
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发表时间：
2020-12-01
影响因子：
5.1
通讯作者：
Fu, Yan-Hui
中科院分区：
文献类型：
--
作者：
Liu, Yun-Yao;Liu, Yan-Ping;Fu, Yan-Hui
通过植物化学研究，分离出三个新的瑞香烷型二萜化合物，分别命名为wikstroechuins A-C（1-3）和八个已知的类似物（4-11）。通过大量的光谱方法确定了新的瑞香烷型二萜化合物（1-3）的结构，并通过与文献报道的光谱数据比较，确定了已知的瑞香烷型二萜化合物（4-11）的结构。评价了所有分离的瑞香烷二萜1-11的抗炎作用以及体外抗HIV活性。结果，瑞香烷二萜1-11显示出对小鼠巨噬细胞RAW 264.7细胞中脂多糖诱导的NO（一氧化氮）产生的显著抑制活性，显示出IC 50值在0.12 +/-0.03至10.58 +/-0.16 μ M的范围内。同时，瑞香烷二萜1-11显示出显着的抗HIV-1逆转录酶（RT）的效果，显示EC 50值范围为0.09509至8.62356 μ M。这些研究结果表明，这些新的具有显著抗炎和抗HIV活性的瑞香烷型二萜化合物的发现是从W。特别是这些新的化合物，对发现新的抗炎药和抗HIV药物及其在保健品和医药品中的潜在实用价值具有重要意义。
A phytochemical investigation on the stems and leaves of Wikstroemia chuii resulted in the isolation of three new daphnane diterpenes, wikstroechuins A-C (1-3), together with eight known analogues (4-11). The structures of new daphnane diterpenes (1-3) were determined on the basis of extensive spectroscopic methods and the known daphnane diterpenes (4-11) were identified by comparing their observable spectroscopic data with those reported spectral data in the literature. The anti-inflammatory effects as well as anti-HIV activities in vitro of all isolated daphnane diterpenes 1-11 were assessed. As a consequence, daphnane diterpenes 1-11 displayed remarkable inhibitory activities on NO (nitric oxide) production induced by lipopolysaccharide in mouse macrophage RAW 264.7 cells showing IC50 values in the range of 0.12 +/- 0.03 to 10.58 +/- 0.16 mu M. Meanwhile, daphnane diterpenes 1-11 displayed significant anti-HIV-1 reverse transcriptase (RT) effects showing EC50 values ranging from 0.09509 to 8.62356 mu M. These research results indicated that the discovery of these new daphnane diterpenes with remarkable anti-inflammatory and anti-HIV activities from W. chuii, especially these new ones, could be extremely meaningful to the discovery of new anti-inflammatory agents and anti-HIV drugs as well as their potential practical values in the health and pharmaceutical products.